| 1 | Sun 12 Sep 2021 | 29 1-1 v FC GroningenFC Groningen 1-1 sc Heerenveen | Dutch Eredivisie |
| 2 | Sat 18 Sep 2021 | 291-0 v Fortuna Sittardsc Heerenveen 1-0 Fortuna Sittard | Dutch Eredivisie |
| 3 | Wed 22 Sep 2021 | 291-3 v FeyenoordFeyenoord 3-1 sc Heerenveen | Dutch Eredivisie |
| 4 | Sun 26 Sep 2021 | 292-3 v FC Twentesc Heerenveen 2-3 FC Twente | Dutch Eredivisie |
| 5 | Sat 2 Oct 2021 | 291-0 v PEC ZwollePEC Zwolle 0-1 sc Heerenveen | Dutch Eredivisie |
| 6 | Sat 16 Oct 2021 | 29 0-2 v Ajaxsc Heerenveen 0-2 Ajax | Dutch Eredivisie |
| 7 | Sat 30 Oct 2021 | 291-2 v Vitessesc Heerenveen 1-2 Vitesse | Dutch Eredivisie |
| 8 | Sat 6 Nov 2021 | 291-1 v NEC NijmegenNEC Nijmegen 1-1 sc Heerenveen | Dutch Eredivisie |
| 9 | Sun 21 Nov 2021 | 292-1 v Willem IIsc Heerenveen 2-1 Willem II | Dutch Eredivisie |
| 10 | Sun 28 Nov 2021 | 291-1 v PSV Eindhovensc Heerenveen 1-1 PSV Eindhoven | Dutch Eredivisie |
| 11 | Sat 4 Dec 2021 | 291-0 v Heracles AlmeloHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
| 12 | Sat 11 Dec 2021 | 290-0 v Sparta Rotterdamsc Heerenveen 0-0 Sparta Rotterdam | Dutch Eredivisie |
| 13 | Wed 22 Dec 2021 | 290-3 v Feyenoordsc Heerenveen 0-3 Feyenoord | Dutch Eredivisie |
| 14 | Sat 22 Jan 2022 | 290-1 v PEC Zwollesc Heerenveen 0-1 PEC Zwolle | Dutch Eredivisie |
| 15 | Sat 5 Feb 2022 | 290-2 v Fortuna SittardFortuna Sittard 2-0 sc Heerenveen | Dutch Eredivisie |
| 16 | Sun 13 Feb 2022 | 290-1 v NEC Nijmegensc Heerenveen 0-1 NEC Nijmegen | Dutch Eredivisie |
| 17 | Sun 20 Feb 2022 | 291-3 v PSV EindhovenPSV Eindhoven 3-1 sc Heerenveen | Dutch Eredivisie |
| 18 | Sun 27 Feb 2022 | 291-2 v FC Utrechtsc Heerenveen 1-2 FC Utrecht | Dutch Eredivisie |
| 19 | Sat 5 Mar 2022 | 290-0 v Willem IIWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 20 | Sat 12 Mar 2022 | 290-0 v RKC WaalwijkRKC Waalwijk 0-0 sc Heerenveen | Dutch Eredivisie |
| 21 | Sun 8 May 2022 | 292-1 v VitesseVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 22 | Wed 11 May 2022 | 290-5 v AjaxAjax 5-0 sc Heerenveen | Dutch Eredivisie |
| 23 | Sun 15 May 2022 | 293-1 v Go Ahead Eaglessc Heerenveen 3-1 Go Ahead Eagles | Dutch Eredivisie |
| 24 | Thu 19 May 2022 | 293-2 v AZ Alkmaarsc Heerenveen 3-2 AZ Alkmaar | Dutch Eredivisie Play-off |
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