| 1 | Sat 15 Jan 2022 | 260-2 v FC TwenteFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 2 | Sat 22 Jan 2022 | 260-1 v PEC Zwollesc Heerenveen 0-1 PEC Zwolle | Dutch Eredivisie |
| 3 | Sat 5 Feb 2022 | 260-2 v Fortuna SittardFortuna Sittard 2-0 sc Heerenveen | Dutch Eredivisie |
| 4 | Sun 13 Feb 2022 | 260-1 v NEC Nijmegensc Heerenveen 0-1 NEC Nijmegen | Dutch Eredivisie |
| 5 | Sun 20 Feb 2022 | 261-3 v PSV EindhovenPSV Eindhoven 3-1 sc Heerenveen | Dutch Eredivisie |
| 6 | Sun 27 Feb 2022 | 261-2 v FC Utrechtsc Heerenveen 1-2 FC Utrecht | Dutch Eredivisie |
| 7 | Sat 5 Mar 2022 | 260-0 v Willem IIWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 8 | Sat 12 Mar 2022 | 260-0 v RKC WaalwijkRKC Waalwijk 0-0 sc Heerenveen | Dutch Eredivisie |
| 9 | Fri 18 Mar 2022 | 262-0 v Heracles Almelosc Heerenveen 2-0 Heracles Almelo | Dutch Eredivisie |
| 10 | Sun 3 Apr 2022 | 261-1 v Sparta RotterdamSparta Rotterdam 1-1 sc Heerenveen | Dutch Eredivisie |
| 11 | Sun 10 Apr 2022 | 263-1 v FC Groningensc Heerenveen 3-1 FC Groningen | Dutch Eredivisie |
| 12 | Sat 23 Apr 2022 | 261-2 v AZ AlkmaarAZ Alkmaar 2-1 sc Heerenveen | Dutch Eredivisie |
| 13 | Sun 8 May 2022 | 262-1 v VitesseVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 14 | Wed 11 May 2022 | 260-5 v AjaxAjax 5-0 sc Heerenveen | Dutch Eredivisie |
| 15 | Sun 15 May 2022 | 263-1 v Go Ahead Eaglessc Heerenveen 3-1 Go Ahead Eagles | Dutch Eredivisie |
| 16 | Thu 19 May 2022 | 263-2 v AZ Alkmaarsc Heerenveen 3-2 AZ Alkmaar | Dutch Eredivisie Play-off |
| 17 | Sun 22 May 2022 | 260-2 v AZ AlkmaarAZ Alkmaar 2-0 sc Heerenveen | Dutch Eredivisie Play-off |
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