| 1 | Sun 8 Aug 2021 | 50-3 v TondelaTondela 3-0 Santa Clara | Portuguese Primeira Liga |
| 2 | Sun 15 Aug 2021 | 52-2 v MoreirenseSanta Clara 2-2 Moreirense | Portuguese Primeira Liga |
| 3 | Thu 26 Aug 2021 | 50-2 v FK PartizanFK Partizan 2-0 Santa Clara | UEFA Europa Conference League |
| 4 | Sun 29 Aug 2021 | 51-0 v Gil VicenteSanta Clara 1-0 Gil Vicente | Portuguese Primeira Liga |
| 5 | Sat 11 Sep 2021 | 50-5 v BenficaSanta Clara 0-5 Benfica | Portuguese Primeira Liga |
| 6 | Sat 2 Oct 2021 | 51-1 v VizelaVizela 1-1 Santa Clara | Portuguese Primeira Liga |
| 7 | Sat 23 Oct 2021 | 50-2 v FamalicãoSanta Clara 0-2 Famalicão | Portuguese Primeira Liga |
| 8 | Sun 31 Oct 2021 | 51-2 v BelenensesBelenenses 2-1 Santa Clara | Portuguese Primeira Liga |
| 9 | Sun 7 Nov 2021 | 50-3 v FC PortoSanta Clara 0-3 FC Porto | Portuguese Primeira Liga |
| 10 | Fri 17 Dec 2021 | 51-0 v Vitória GuimarãesSanta Clara 1-0 Vitória Guimarães | Portuguese Primeira Liga |
| 11 | Thu 30 Dec 2021 | 51-2 v Paços de FerreiraPaços de Ferreira 2-1 Santa Clara | Portuguese Primeira Liga |
| 12 | Fri 7 Jan 2022 | 53-2 v Sporting LisbonSanta Clara 3-2 Sporting Lisbon | Portuguese Primeira Liga |
| 13 | Sun 16 Jan 2022 | 52-2 v TondelaSanta Clara 2-2 Tondela | Portuguese Primeira Liga |
| 14 | Mon 28 Feb 2022 | 50-0 v Sporting BragaSporting Braga 0-0 Santa Clara | Portuguese Primeira Liga |
| 15 | Sun 8 May 2022 | 52-0 v Paços de FerreiraSanta Clara 2-0 Paços de Ferreira | Portuguese Primeira Liga |
| 16 | Sat 14 May 2022 | 50-4 v Sporting LisbonSporting Lisbon 4-0 Santa Clara | Portuguese Primeira Liga |
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