| 1 | Sat 20 Nov 2021 | 422-0 v Harrogate TownHarrogate Town 0-2 Salford City | Sky Bet League Two |
| 2 | Sat 11 Dec 2021 | 421-2 v Mansfield TownMansfield Town 2-1 Salford City | Sky Bet League Two |
| 3 | Sat 18 Dec 2021 | 421-0 v StevenageSalford City 1-0 Stevenage | Sky Bet League Two |
| 4 | Sat 8 Jan 2022 | 422-0 v Newport CountyNewport County 0-2 Salford City | Sky Bet League Two |
| 5 | Tue 11 Jan 2022 | 421-1 v Tranmere RoversSalford City 1-1 Tranmere Rovers | Sky Bet League Two |
| 6 | Sat 15 Jan 2022 | 42 1-2 v Bradford CityBradford City 2-1 Salford City | Sky Bet League Two |
| 7 | Tue 18 Jan 2022 | 421-0 v Port ValePort Vale 0-1 Salford City | Sky Bet League Two |
| 8 | Sat 22 Jan 2022 | 420-3 v Colchester UnitedSalford City 0-3 Colchester United | Sky Bet League Two |
| 9 | Tue 25 Jan 2022 | 422-0 v BarrowBarrow 0-2 Salford City | Sky Bet League Two |
| 10 | Tue 8 Feb 2022 | 420-0 v Sutton UnitedSutton United 0-0 Salford City | Sky Bet League Two |
| 11 | Sat 12 Feb 2022 | 422-0 v Leyton OrientLeyton Orient 0-2 Salford City | Sky Bet League Two |
| 12 | Sat 26 Feb 2022 | 422-1 v Swindon TownSwindon Town 1-2 Salford City | Sky Bet League Two |
| 13 | Sat 5 Mar 2022 | 42 1-1 v Forest Green RoversSalford City 1-1 Forest Green Rovers | Sky Bet League Two |
| 14 | Sat 12 Mar 2022 | 420-0 v Exeter CityExeter City 0-0 Salford City | Sky Bet League Two |
| 15 | Tue 15 Mar 2022 | 421-1 v RochdaleRochdale 1-1 Salford City | Sky Bet League Two |
| 16 | Sat 19 Mar 2022 | 425-1 v Scunthorpe UnitedSalford City 5-1 Scunthorpe United | Sky Bet League Two |
| 17 | Sat 26 Mar 2022 | 422-1 v WalsallSalford City 2-1 Walsall | Sky Bet League Two |
| 18 | Tue 29 Mar 2022 | 422-1 v Crawley TownSalford City 2-1 Crawley Town | Sky Bet League Two |
| 19 | Sat 2 Apr 2022 | 422-0 v Hartlepool UnitedHartlepool United 0-2 Salford City | Sky Bet League Two |
| 20 | Tue 5 Apr 2022 | 420-1 v Port ValeSalford City 0-1 Port Vale | Sky Bet League Two |
| 21 | Sat 9 Apr 2022 | 422-0 v Harrogate TownSalford City 2-0 Harrogate Town | Sky Bet League Two |
| 22 | Fri 15 Apr 2022 | 420-1 v Bristol RoversBristol Rovers 1-0 Salford City | Sky Bet League Two |
| 23 | Mon 18 Apr 2022 | 422-2 v BarrowSalford City 2-2 Barrow | Sky Bet League Two |
| 24 | Sat 23 Apr 2022 | 422-1 v Oldham AthleticOldham Athletic 1-2 Salford City | Sky Bet League Two |
| 25 | Mon 2 May 2022 | 422-2 v Mansfield TownSalford City 2-2 Mansfield Town | Sky Bet League Two |
| 26 | Sat 7 May 2022 | 422-4 v StevenageStevenage 4-2 Salford City | Sky Bet League Two |
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