| 1 | Sat 11 Sep 2021 | 701-0 v KAS EupenKAS Eupen 0-1 Royal Antwerp | Belgian First Division A |
| 2 | Thu 16 Sep 2021 | 701-2 v OlympiakosOlympiakos 2-1 Royal Antwerp | UEFA Europa League Group D |
| 3 | Wed 22 Sep 2021 | 704-2 v KRC GenkRoyal Antwerp 4-2 KRC Genk | Belgian First Division A |
| 4 | Thu 30 Sep 2021 | 700-1 v Eintracht FrankfurtRoyal Antwerp 0-1 Eintracht Frankfurt | UEFA Europa League Group D |
| 5 | Sun 3 Oct 2021 | 701-0 v KAA GentRoyal Antwerp 1-0 KAA Gent | Belgian First Division A |
| 6 | Sat 16 Oct 2021 | 701-2 v SV Zulte WaregemSV Zulte Waregem 2-1 Royal Antwerp | Belgian First Division A |
| 7 | Thu 21 Oct 2021 | 702-2 v FenerbahçeFenerbahçe 2-2 Royal Antwerp | UEFA Europa League Group D |
| 8 | Sun 24 Oct 2021 | 701-1 v Club BruggeRoyal Antwerp 1-1 Club Brugge | Belgian First Division A |
| 9 | Sun 31 Oct 2021 | 70 1-0 v Cercle BruggeCercle Brugge 0-1 Royal Antwerp | Belgian First Division A |
| 10 | Thu 4 Nov 2021 | 700-3 v FenerbahçeRoyal Antwerp 0-3 Fenerbahçe | UEFA Europa League Group D |
| 11 | Sun 7 Nov 2021 | 702-0 v RSC AnderlechtRoyal Antwerp 2-0 RSC Anderlecht | Belgian First Division A |
| 12 | Sun 21 Nov 2021 | 701-2 v Sint-Truidense VVSint-Truidense VV 2-1 Royal Antwerp | Belgian First Division A |
| 13 | Thu 25 Nov 2021 | 702-2 v Eintracht FrankfurtEintracht Frankfurt 2-2 Royal Antwerp | UEFA Europa League Group D |
| 14 | Sun 28 Nov 2021 | 703-0 v KV OostendeRoyal Antwerp 3-0 KV Oostende | Belgian First Division A |
| 15 | Sun 5 Dec 2021 | 70 1-0 v Germinal BeerschotGerminal Beerschot 0-1 Royal Antwerp | Belgian First Division A |
| 16 | Thu 9 Dec 2021 | 701-0 v OlympiakosRoyal Antwerp 1-0 Olympiakos | UEFA Europa League Group D |
| 17 | Sun 12 Dec 2021 | 70 2-3 v Standard LiègeRoyal Antwerp 2-3 Standard Liège | Belgian First Division A |
| 18 | Thu 16 Dec 2021 | 704-2 v KAS EupenRoyal Antwerp 4-2 KAS Eupen | Belgian First Division A |
| 19 | Sun 16 Jan 2022 | 703-0 v Sporting de CharleroiRoyal Antwerp 3-0 Sporting de Charleroi | Belgian First Division A |
| 20 | Fri 21 Jan 2022 | 702-1 v KV OostendeKV Oostende 1-2 Royal Antwerp | Belgian First Division A |
| 21 | Tue 25 Jan 2022 | 701-1 v Sint-Truidense VVRoyal Antwerp 1-1 Sint-Truidense VV | Belgian First Division A |
| 22 | Sun 30 Jan 2022 | 701-0 v KAA GentKAA Gent 0-1 Royal Antwerp | Belgian First Division A |
| 23 | Wed 2 Feb 2022 | 702-0 v KV KortrijkKV Kortrijk 0-2 Royal Antwerp | Belgian First Division A |
| 24 | Fri 11 Feb 2022 | 70 1-0 v SeraingSeraing 0-1 Royal Antwerp | Belgian First Division A |
| 25 | Sun 20 Feb 2022 | 701-2 v MechelenRoyal Antwerp 1-2 Mechelen | Belgian First Division A |
| 26 | Sun 27 Feb 2022 | 701-4 v Club BruggeClub Brugge 4-1 Royal Antwerp | Belgian First Division A |
| 27 | Sun 6 Mar 2022 | 702-1 v Germinal BeerschotRoyal Antwerp 2-1 Germinal Beerschot | Belgian First Division A |
| 28 | Sun 13 Mar 2022 | 701-2 v RSC AnderlechtRSC Anderlecht 2-1 Royal Antwerp | Belgian First Division A |
| 29 | Sat 19 Mar 2022 | 701-0 v SV Zulte WaregemRoyal Antwerp 1-0 SV Zulte Waregem | Belgian First Division A |
| 30 | Sat 9 Apr 2022 | 701-1 v Cercle BruggeRoyal Antwerp 1-1 Cercle Brugge | Belgian First Division A |
| 31 | Sun 1 May 2022 | 700-0 v Union Saint-GilloiseRoyal Antwerp 0-0 Union Saint-Gilloise | Belgian First Division A Play-off |
| 32 | Sun 8 May 2022 | 700-4 v RSC AnderlechtRoyal Antwerp 0-4 RSC Anderlecht | Belgian First Division A Play-off |
| 33 | Thu 12 May 2022 | 701-2 v RSC AnderlechtRSC Anderlecht 2-1 Royal Antwerp | Belgian First Division A Play-off |
| 34 | Sun 15 May 2022 | 701-3 v Club BruggeRoyal Antwerp 1-3 Club Brugge | Belgian First Division A Play-off |
| 35 | Sun 22 May 2022 | 701-0 v Union Saint-GilloiseUnion Saint-Gilloise 0-1 Royal Antwerp | Belgian First Division A Play-off |