| 1 | Sat 14 Aug 2021 | 164-1 v AlavésAlavés 1-4 Real Madrid | Spanish La Liga |
| 2 | Sun 22 Aug 2021 | 163-3 v LevanteLevante 3-3 Real Madrid | Spanish La Liga |
| 3 | Sun 19 Sep 2021 | 162-1 v ValenciaValencia 1-2 Real Madrid | Spanish La Liga |
| 4 | Wed 22 Sep 2021 | 166-1 v MallorcaReal Madrid 6-1 Mallorca | Spanish La Liga |
| 5 | Tue 28 Sep 2021 | 16 1-2 v FC TiraspolReal Madrid 1-2 FC Tiraspol | UEFA Champions League Group D |
| 6 | Sun 3 Oct 2021 | 161-2 v EspanyolEspanyol 2-1 Real Madrid | Spanish La Liga |
| 7 | Wed 3 Nov 2021 | 162-1 v Shakhtar DonetskReal Madrid 2-1 Shakhtar Donetsk | UEFA Champions League Group D |
| 8 | Sun 21 Nov 2021 | 164-1 v GranadaGranada 1-4 Real Madrid | Spanish La Liga |
| 9 | Sat 4 Dec 2021 | 162-0 v Real SociedadReal Sociedad 0-2 Real Madrid | Spanish La Liga |
| 10 | Tue 7 Dec 2021 | 162-0 v Inter MilanReal Madrid 2-0 Inter Milan | UEFA Champions League Group D |
| 11 | Sun 12 Dec 2021 | 162-0 v Atlético MadridReal Madrid 2-0 Atlético Madrid | Spanish La Liga |
| 12 | Sun 19 Dec 2021 | 160-0 v CádizReal Madrid 0-0 Cádiz | Spanish La Liga |
| 13 | Wed 22 Dec 2021 | 162-1 v Athletic BilbaoAthletic Bilbao 1-2 Real Madrid | Spanish La Liga |
| 14 | Sun 23 Jan 2022 | 162-2 v ElcheReal Madrid 2-2 Elche | Spanish La Liga |
| 15 | Sun 6 Feb 2022 | 161-0 v GranadaReal Madrid 1-0 Granada | Spanish La Liga |
| 16 | Sat 12 Feb 2022 | 160-0 v VillarrealVillarreal 0-0 Real Madrid | Spanish La Liga |
| 17 | Thu 12 May 2022 | 166-0 v LevanteReal Madrid 6-0 Levante | Spanish La Liga |
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