| 1 | Sat 14 Aug 2021 | 44-1 v AlavésAlavés 1-4 Real Madrid | Spanish La Liga |
| 2 | Sun 22 Aug 2021 | 43-3 v LevanteLevante 3-3 Real Madrid | Spanish La Liga |
| 3 | Sat 28 Aug 2021 | 41-0 v Real BetisReal Betis 0-1 Real Madrid | Spanish La Liga |
| 4 | Wed 15 Sep 2021 | 4 1-0 v Inter MilanInter Milan 0-1 Real Madrid | UEFA Champions League Group D |
| 5 | Sun 19 Sep 2021 | 42-1 v ValenciaValencia 1-2 Real Madrid | Spanish La Liga |
| 6 | Wed 22 Sep 2021 | 46-1 v MallorcaReal Madrid 6-1 Mallorca | Spanish La Liga |
| 7 | Sat 25 Sep 2021 | 40-0 v VillarrealReal Madrid 0-0 Villarreal | Spanish La Liga |
| 8 | Tue 28 Sep 2021 | 41-2 v FC TiraspolReal Madrid 1-2 FC Tiraspol | UEFA Champions League Group D |
| 9 | Sun 3 Oct 2021 | 41-2 v EspanyolEspanyol 2-1 Real Madrid | Spanish La Liga |
| 10 | Tue 19 Oct 2021 | 45-0 v Shakhtar DonetskShakhtar Donetsk 0-5 Real Madrid | UEFA Champions League Group D |
| 11 | Sun 24 Oct 2021 | 42-1 v BarcelonaBarcelona 1-2 Real Madrid | Spanish La Liga |
| 12 | Wed 27 Oct 2021 | 40-0 v OsasunaReal Madrid 0-0 Osasuna | Spanish La Liga |
| 13 | Sat 30 Oct 2021 | 42-1 v ElcheElche 1-2 Real Madrid | Spanish La Liga |
| 14 | Wed 3 Nov 2021 | 42-1 v Shakhtar DonetskReal Madrid 2-1 Shakhtar Donetsk | UEFA Champions League Group D |
| 15 | Sat 6 Nov 2021 | 42-1 v Rayo VallecanoReal Madrid 2-1 Rayo Vallecano | Spanish La Liga |
| 16 | Sun 21 Nov 2021 | 44-1 v GranadaGranada 1-4 Real Madrid | Spanish La Liga |
| 17 | Wed 24 Nov 2021 | 43-0 v FC TiraspolFC Tiraspol 0-3 Real Madrid | UEFA Champions League Group D |
| 18 | Sun 28 Nov 2021 | 42-1 v SevillaReal Madrid 2-1 Sevilla | Spanish La Liga |
| 19 | Wed 1 Dec 2021 | 41-0 v Athletic BilbaoReal Madrid 1-0 Athletic Bilbao | Spanish La Liga |
| 20 | Sat 4 Dec 2021 | 42-0 v Real SociedadReal Sociedad 0-2 Real Madrid | Spanish La Liga |
| 21 | Tue 7 Dec 2021 | 42-0 v Inter MilanReal Madrid 2-0 Inter Milan | UEFA Champions League Group D |
| 22 | Sun 12 Dec 2021 | 4 2-0 v Atlético MadridReal Madrid 2-0 Atlético Madrid | Spanish La Liga |
| 23 | Sun 19 Dec 2021 | 40-0 v CádizReal Madrid 0-0 Cádiz | Spanish La Liga |
| 24 | Sun 2 Jan 2022 | 40-1 v GetafeGetafe 1-0 Real Madrid | Spanish La Liga |
| 25 | Sat 8 Jan 2022 | 44-1 v ValenciaReal Madrid 4-1 Valencia | Spanish La Liga |
| 26 | Sun 23 Jan 2022 | 4 2-2 v ElcheReal Madrid 2-2 Elche | Spanish La Liga |
| 27 | Sun 6 Feb 2022 | 41-0 v GranadaReal Madrid 1-0 Granada | Spanish La Liga |
| 28 | Sat 12 Feb 2022 | 40-0 v VillarrealVillarreal 0-0 Real Madrid | Spanish La Liga |
| 29 | Tue 15 Feb 2022 | 40-1 v Paris St GermainParis St Germain 1-0 Real Madrid | UEFA Champions League Round of 16 |
| 30 | Sat 19 Feb 2022 | 43-0 v AlavésReal Madrid 3-0 Alavés | Spanish La Liga |
| 31 | Sat 5 Mar 2022 | 44-1 v Real SociedadReal Madrid 4-1 Real Sociedad | Spanish La Liga |
| 32 | Wed 9 Mar 2022 | 43-1 v Paris St GermainReal Madrid 3-1 Paris St Germain | UEFA Champions League Round of 16 |
| 33 | Mon 14 Mar 2022 | 43-0 v MallorcaMallorca 0-3 Real Madrid | Spanish La Liga |
| 34 | Sun 20 Mar 2022 | 40-4 v BarcelonaReal Madrid 0-4 Barcelona | Spanish La Liga |
| 35 | Sat 2 Apr 2022 | 42-1 v Celta VigoCelta Vigo 1-2 Real Madrid | Spanish La Liga |
| 36 | Wed 6 Apr 2022 | 43-1 v ChelseaChelsea 1-3 Real Madrid | UEFA Champions League Quarter Final |
| 37 | Sat 9 Apr 2022 | 42-0 v GetafeReal Madrid 2-0 Getafe | Spanish La Liga |
| 38 | Tue 12 Apr 2022 | 42-3 v ChelseaReal Madrid 2-3 Chelsea | UEFA Champions League Quarter Final |
| 39 | Sun 17 Apr 2022 | 43-2 v SevillaSevilla 2-3 Real Madrid | Spanish La Liga |
| 40 | Wed 20 Apr 2022 | 43-1 v OsasunaOsasuna 1-3 Real Madrid | Spanish La Liga |
| 41 | Tue 26 Apr 2022 | 43-4 v Manchester CityManchester City 4-3 Real Madrid | UEFA Champions League Semi Final |
| 42 | Sat 28 May 2022 | 41-0 v LiverpoolLiverpool 0-1 Real Madrid | UEFA Champions League Final |
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