| 1 | Fri 22 Aug | 161-0 v AlavésReal Betis 1-0 Alavés | Spanish La Liga |
| 2 | Wed 27 Aug | 161-1 v Celta VigoCelta Vigo 1-1 Real Betis | Spanish La Liga |
| 3 | Sun 14 Sep | 162-2 v LevanteLevante 2-2 Real Betis | Spanish La Liga |
| 4 | Fri 19 Sep | 163-1 v Real SociedadReal Betis 3-1 Real Sociedad | Spanish La Liga |
| 5 | Wed 24 Sep | 162-2 v Nottingham ForestReal Betis 2-2 Nottingham Forest | UEFA Europa League Matchday 1 |
| 6 | Sun 28 Sep | 162-0 v OsasunaReal Betis 2-0 Osasuna | Spanish La Liga |
| 7 | Thu 2 Oct | 162-0 v LudogoretsLudogorets 0-2 Real Betis | UEFA Europa League Matchday 2 |
| 8 | Sun 5 Oct | 16 2-1 v EspanyolEspanyol 1-2 Real Betis | Spanish La Liga |
| 9 | Sat 18 Oct | 162-2 v VillarrealVillarreal 2-2 Real Betis | Spanish La Liga |
| 10 | Thu 23 Oct | 160-0 v KRC GenkKRC Genk 0-0 Real Betis | UEFA Europa League Matchday 3 |
| 11 | Sun 2 Nov | 163-0 v MallorcaReal Betis 3-0 Mallorca | Spanish La Liga |
| 12 | Thu 6 Nov | 162-0 v Olympique LyonnaisReal Betis 2-0 Olympique Lyonnais | UEFA Europa League Matchday 4 |
| 13 | Sun 9 Nov | 16 1-1 v ValenciaValencia 1-1 Real Betis | Spanish La Liga |
| 14 | Sun 23 Nov | 161-1 v GironaReal Betis 1-1 Girona | Spanish La Liga |
| 15 | Sun 30 Nov | 162-0 v SevillaSevilla 0-2 Real Betis | Spanish La Liga |
| 16 | Sat 6 Dec | 16 3-5 v BarcelonaReal Betis 3-5 Barcelona | Spanish La Liga |
| 17 | Thu 11 Dec | 16 3-1 v Dinamo ZagrebDinamo Zagreb 1-3 Real Betis | UEFA Europa League Matchday 6 |
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