| 1 | Mon 18 Aug | 4 1-1 v ElcheElche 1-1 Real Betis | Spanish La Liga |
| 2 | Fri 22 Aug | 41-0 v AlavésReal Betis 1-0 Alavés | Spanish La Liga |
| 3 | Wed 27 Aug | 41-1 v Celta VigoCelta Vigo 1-1 Real Betis | Spanish La Liga |
| 4 | Sun 31 Aug | 41-2 v Athletic BilbaoReal Betis 1-2 Athletic Bilbao | Spanish La Liga |
| 5 | Sun 14 Sep | 4 2-2 v LevanteLevante 2-2 Real Betis | Spanish La Liga |
| 6 | Fri 19 Sep | 4 3-1 v Real SociedadReal Betis 3-1 Real Sociedad | Spanish La Liga |
| 7 | Wed 24 Sep | 4 2-2 v Nottingham ForestReal Betis 2-2 Nottingham Forest | UEFA Europa League Matchday 1 |
| 8 | Sun 28 Sep | 42-0 v OsasunaReal Betis 2-0 Osasuna | Spanish La Liga |
| 9 | Thu 2 Oct | 42-0 v LudogoretsLudogorets 0-2 Real Betis | UEFA Europa League Matchday 2 |
| 10 | Sun 5 Oct | 42-1 v EspanyolEspanyol 1-2 Real Betis | Spanish La Liga |
| 11 | Sat 18 Oct | 42-2 v VillarrealVillarreal 2-2 Real Betis | Spanish La Liga |
| 12 | Mon 27 Oct | 40-2 v Atlético MadridReal Betis 0-2 Atlético Madrid | Spanish La Liga |
| 13 | Sun 2 Nov | 43-0 v MallorcaReal Betis 3-0 Mallorca | Spanish La Liga |
| 14 | Thu 6 Nov | 42-0 v Olympique LyonnaisReal Betis 2-0 Olympique Lyonnais | UEFA Europa League Matchday 4 |
| 15 | Sun 9 Nov | 4 1-1 v ValenciaValencia 1-1 Real Betis | Spanish La Liga |
| 16 | Sun 23 Nov | 41-1 v GironaReal Betis 1-1 Girona | Spanish La Liga |
| 17 | Thu 27 Nov | 42-1 v FC UtrechtReal Betis 2-1 FC Utrecht | UEFA Europa League Matchday 5 |
| 18 | Sun 30 Nov | 42-0 v SevillaSevilla 0-2 Real Betis | Spanish La Liga |
| 19 | Sat 6 Dec | 43-5 v BarcelonaReal Betis 3-5 Barcelona | Spanish La Liga |
| 20 | Thu 11 Dec | 43-1 v Dinamo ZagrebDinamo Zagreb 1-3 Real Betis | UEFA Europa League Matchday 6 |
| 21 | Mon 15 Dec | 40-0 v Rayo VallecanoRayo Vallecano 0-0 Real Betis | Spanish La Liga |
| 22 | Sun 21 Dec | 44-0 v GetafeReal Betis 4-0 Getafe | Spanish La Liga |
| 23 | Sun 4 Jan | 41-5 v Real MadridReal Madrid 5-1 Real Betis | Spanish La Liga |
| 24 | Sat 17 Jan | 42-0 v VillarrealReal Betis 2-0 Villarreal | Spanish La Liga |
| 25 | Sun 25 Jan | 4 1-2 v AlavésAlavés 2-1 Real Betis | Spanish La Liga |
| 26 | Thu 29 Jan | 42-1 v FeyenoordReal Betis 2-1 Feyenoord | UEFA Europa League Matchday 8 |
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