| 1 | Mon 15 Aug 2022 | 53-0 v ElcheReal Betis 3-0 Elche | Spanish La Liga |
| 2 | Sat 20 Aug 2022 | 5 2-1 v MallorcaMallorca 1-2 Real Betis | Spanish La Liga |
| 3 | Fri 26 Aug 2022 | 51-0 v OsasunaReal Betis 1-0 Osasuna | Spanish La Liga |
| 4 | Sat 3 Sep 2022 | 51-2 v Real MadridReal Madrid 2-1 Real Betis | Spanish La Liga |
| 5 | Thu 8 Sep 2022 | 52-0 v HJK HelsinkiHJK Helsinki 0-2 Real Betis | UEFA Europa League Group C |
| 6 | Sun 11 Sep 2022 | 51-0 v VillarrealReal Betis 1-0 Villarreal | Spanish La Liga |
| 7 | Thu 15 Sep 2022 | 53-2 v LudogoretsReal Betis 3-2 Ludogorets | UEFA Europa League Group C |
| 8 | Sun 18 Sep 2022 | 52-1 v GironaReal Betis 2-1 Girona | Spanish La Liga |
| 9 | Thu 6 Oct 2022 | 52-1 v RomaRoma 1-2 Real Betis | UEFA Europa League Group C |
| 10 | Sun 9 Oct 2022 | 50-0 v Real ValladolidReal Valladolid 0-0 Real Betis | Spanish La Liga |
| 11 | Thu 13 Oct 2022 | 51-1 v RomaReal Betis 1-1 Roma | UEFA Europa League Group C |
| 12 | Sun 16 Oct 2022 | 53-1 v AlmeríaReal Betis 3-1 Almería | Spanish La Liga |
| 13 | Wed 19 Oct 2022 | 50-0 v CádizCádiz 0-0 Real Betis | Spanish La Liga |
| 14 | Sun 23 Oct 2022 | 5 1-2 v Atlético MadridReal Betis 1-2 Atlético Madrid | Spanish La Liga |
| 15 | Thu 27 Oct 2022 | 51-0 v LudogoretsLudogorets 0-1 Real Betis | UEFA Europa League Group C |
| 16 | Sun 6 Nov 2022 | 51-1 v SevillaReal Betis 1-1 Sevilla | Spanish La Liga |
| 17 | Thu 10 Nov 2022 | 50-3 v ValenciaValencia 3-0 Real Betis | Spanish La Liga |
| 18 | Sun 8 Jan 2023 | 52-1 v Rayo VallecanoRayo Vallecano 1-2 Real Betis | Spanish La Liga |
| 19 | Sat 21 Jan 2023 | 5 0-1 v EspanyolEspanyol 1-0 Real Betis | Spanish La Liga |
| 20 | Sat 28 Jan 2023 | 51-0 v GetafeGetafe 0-1 Real Betis | Spanish La Liga |
| 21 | Wed 1 Feb 2023 | 51-2 v BarcelonaReal Betis 1-2 Barcelona | Spanish La Liga |
| 22 | Sat 4 Feb 2023 | 53-4 v Celta VigoReal Betis 3-4 Celta Vigo | Spanish La Liga |
| 23 | Sat 11 Feb 2023 | 5 3-2 v AlmeríaAlmería 2-3 Real Betis | Spanish La Liga |
| 24 | Sat 18 Feb 2023 | 5 2-1 v Real ValladolidReal Betis 2-1 Real Valladolid | Spanish La Liga |
| 25 | Sun 5 Mar 2023 | 50-0 v Real MadridReal Betis 0-0 Real Madrid | Spanish La Liga |
| 26 | Thu 9 Mar 2023 | 51-4 v Manchester UnitedManchester United 4-1 Real Betis | UEFA Europa League Round of 16 |
| 27 | Sun 12 Mar 2023 | 5 1-1 v VillarrealVillarreal 1-1 Real Betis | Spanish La Liga |
| 28 | Thu 16 Mar 2023 | 50-1 v Manchester UnitedReal Betis 0-1 Manchester United | UEFA Europa League Round of 16 |
| 29 | Sun 19 Mar 2023 | 51-0 v MallorcaReal Betis 1-0 Mallorca | Spanish La Liga |
| 30 | Sun 2 Apr 2023 | 50-1 v Atlético MadridAtlético Madrid 1-0 Real Betis | Spanish La Liga |
| 31 | Sun 9 Apr 2023 | 50-2 v CádizReal Betis 0-2 Cádiz | Spanish La Liga |
| 32 | Sat 15 Apr 2023 | 53-1 v EspanyolReal Betis 3-1 Espanyol | Spanish La Liga |
| 33 | Sat 22 Apr 2023 | 52-3 v OsasunaOsasuna 3-2 Real Betis | Spanish La Liga |
| 34 | Tue 25 Apr 2023 | 5 0-0 v Real SociedadReal Betis 0-0 Real Sociedad | Spanish La Liga |
| 35 | Sat 29 Apr 2023 | 50-4 v BarcelonaBarcelona 4-0 Real Betis | Spanish La Liga |
| 36 | Thu 4 May 2023 | 51-0 v Athletic BilbaoAthletic Bilbao 0-1 Real Betis | Spanish La Liga |
| 37 | Mon 15 May 2023 | 53-1 v Rayo VallecanoReal Betis 3-1 Rayo Vallecano | Spanish La Liga |
| 38 | Sun 21 May 2023 | 50-0 v SevillaSevilla 0-0 Real Betis | Spanish La Liga |
| 39 | Wed 24 May 2023 | 50-1 v GetafeReal Betis 0-1 Getafe | Spanish La Liga |
| 40 | Sun 28 May 2023 | 5 2-1 v GironaGirona 1-2 Real Betis | Spanish La Liga |
| 41 | Sun 4 Jun 2023 | 51-1 v ValenciaReal Betis 1-1 Valencia | Spanish La Liga |
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