| 1 | Fri 21 Jan 2022 | 234-1 v EspanyolEspanyol 1-4 Real Betis | Spanish La Liga |
| 2 | Thu 17 Feb 2022 | 233-2 v Zenit St PetersburgZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 3 | Sun 6 Mar 2022 | 231-3 v Atlético MadridReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 4 | Wed 9 Mar 2022 | 231-2 v Eintracht FrankfurtReal Betis 1-2 Eintracht Frankfurt | UEFA Europa League Round of 16 |
| 5 | Sun 13 Mar 2022 | 231-0 v Athletic BilbaoReal Betis 1-0 Athletic Bilbao | Spanish La Liga |
| 6 | Thu 17 Mar 2022 | 231-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Real Betis | UEFA Europa League Round of 16 |
| 7 | Sun 3 Apr 2022 | 234-1 v OsasunaReal Betis 4-1 Osasuna | Spanish La Liga |
| 8 | Sat 9 Apr 2022 | 23 2-1 v CádizCádiz 1-2 Real Betis | Spanish La Liga |
| 9 | Tue 19 Apr 2022 | 230-1 v ElcheReal Betis 0-1 Elche | Spanish La Liga |
| 10 | Mon 2 May 2022 | 230-0 v GetafeGetafe 0-0 Real Betis | Spanish La Liga |
| 11 | Sat 7 May 2022 | 231-2 v BarcelonaReal Betis 1-2 Barcelona | Spanish La Liga |
| 12 | Tue 10 May 2022 | 233-0 v ValenciaValencia 0-3 Real Betis | Spanish La Liga |
| 13 | Fri 20 May 2022 | 230-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
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