| 1 | Sat 14 Aug 2021 | 131-1 v MallorcaMallorca 1-1 Real Betis | Spanish La Liga |
| 2 | Fri 20 Aug 2021 | 13 1-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 3 | Sat 28 Aug 2021 | 130-1 v Real MadridReal Betis 0-1 Real Madrid | Spanish La Liga |
| 4 | Mon 13 Sep 2021 | 132-1 v GranadaGranada 1-2 Real Betis | Spanish La Liga |
| 5 | Thu 30 Sep 2021 | 133-1 v Ferencvárosi TCFerencvárosi TC 1-3 Real Betis | UEFA Europa League Group G |
| 6 | Sun 3 Oct 2021 | 130-2 v VillarrealVillarreal 2-0 Real Betis | Spanish La Liga |
| 7 | Mon 18 Oct 2021 | 131-0 v AlavésAlavés 0-1 Real Betis | Spanish La Liga |
| 8 | Thu 4 Nov 2021 | 130-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-0 Real Betis | UEFA Europa League Group G |
| 9 | Sun 21 Nov 2021 | 133-0 v ElcheElche 0-3 Real Betis | Spanish La Liga |
| 10 | Thu 25 Nov 2021 | 132-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 11 | Sun 28 Nov 2021 | 133-1 v LevanteReal Betis 3-1 Levante | Spanish La Liga |
| 12 | Sat 4 Dec 2021 | 131-0 v BarcelonaBarcelona 0-1 Real Betis | Spanish La Liga |
| 13 | Thu 9 Dec 2021 | 132-3 v CelticCeltic 3-2 Real Betis | UEFA Europa League Group G |
| 14 | Sun 12 Dec 2021 | 134-0 v Real SociedadReal Betis 4-0 Real Sociedad | Spanish La Liga |
| 15 | Sun 19 Dec 2021 | 132-3 v Athletic BilbaoAthletic Bilbao 3-2 Real Betis | Spanish La Liga |
| 16 | Sun 2 Jan 2022 | 130-2 v Celta VigoReal Betis 0-2 Celta Vigo | Spanish La Liga |
| 17 | Sun 9 Jan 2022 | 13 1-1 v Rayo VallecanoRayo Vallecano 1-1 Real Betis | Spanish La Liga |
| 18 | Sun 6 Feb 2022 | 130-2 v VillarrealReal Betis 0-2 Villarreal | Spanish La Liga |
| 19 | Sun 13 Feb 2022 | 134-2 v LevanteLevante 2-4 Real Betis | Spanish La Liga |
| 20 | Thu 17 Feb 2022 | 133-2 v Zenit St PetersburgZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 21 | Sun 20 Feb 2022 | 132-1 v MallorcaReal Betis 2-1 Mallorca | Spanish La Liga |
| 22 | Thu 24 Feb 2022 | 130-0 v Zenit St PetersburgReal Betis 0-0 Zenit St Petersburg | UEFA Europa League Round of 32 |
| 23 | Sun 13 Mar 2022 | 131-0 v Athletic BilbaoReal Betis 1-0 Athletic Bilbao | Spanish La Liga |
| 24 | Thu 17 Mar 2022 | 131-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Real Betis | UEFA Europa League Round of 16 |
| 25 | Tue 19 Apr 2022 | 130-1 v ElcheReal Betis 0-1 Elche | Spanish La Liga |
| 26 | Sat 7 May 2022 | 131-2 v BarcelonaReal Betis 1-2 Barcelona | Spanish La Liga |
| 27 | Tue 10 May 2022 | 133-0 v ValenciaValencia 0-3 Real Betis | Spanish La Liga |
| 28 | Sun 15 May 2022 | 132-0 v GranadaReal Betis 2-0 Granada | Spanish La Liga |
| 29 | Fri 20 May 2022 | 130-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
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