| 1 | Fri 20 Aug 2021 | 33 1-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 2 | Sat 28 Aug 2021 | 330-1 v Real MadridReal Betis 0-1 Real Madrid | Spanish La Liga |
| 3 | Thu 16 Sep 2021 | 334-3 v CelticReal Betis 4-3 Celtic | UEFA Europa League Group G |
| 4 | Sun 26 Sep 2021 | 332-0 v GetafeReal Betis 2-0 Getafe | Spanish La Liga |
| 5 | Sun 3 Oct 2021 | 330-2 v VillarrealVillarreal 2-0 Real Betis | Spanish La Liga |
| 6 | Thu 21 Oct 2021 | 33 1-1 v Bayer 04 LeverkusenReal Betis 1-1 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 7 | Thu 4 Nov 2021 | 330-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-0 Real Betis | UEFA Europa League Group G |
| 8 | Thu 25 Nov 2021 | 332-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 9 | Thu 9 Dec 2021 | 332-3 v CelticCeltic 3-2 Real Betis | UEFA Europa League Group G |
| 10 | Sun 12 Dec 2021 | 334-0 v Real SociedadReal Betis 4-0 Real Sociedad | Spanish La Liga |
| 11 | Sun 19 Dec 2021 | 332-3 v Athletic BilbaoAthletic Bilbao 3-2 Real Betis | Spanish La Liga |
| 12 | Tue 18 Jan 2022 | 334-0 v AlavésReal Betis 4-0 Alavés | Spanish La Liga |
| 13 | Sun 6 Feb 2022 | 330-2 v VillarrealReal Betis 0-2 Villarreal | Spanish La Liga |
| 14 | Wed 9 Mar 2022 | 331-2 v Eintracht FrankfurtReal Betis 1-2 Eintracht Frankfurt | UEFA Europa League Round of 16 |
| 15 | Sun 13 Mar 2022 | 33 1-0 v Athletic BilbaoReal Betis 1-0 Athletic Bilbao | Spanish La Liga |
| 16 | Thu 17 Mar 2022 | 331-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Real Betis | UEFA Europa League Round of 16 |
| 17 | Sun 20 Mar 2022 | 330-0 v Celta VigoCelta Vigo 0-0 Real Betis | Spanish La Liga |
| 18 | Tue 19 Apr 2022 | 330-1 v ElcheReal Betis 0-1 Elche | Spanish La Liga |
| 19 | Tue 10 May 2022 | 333-0 v ValenciaValencia 0-3 Real Betis | Spanish La Liga |
| 20 | Sun 15 May 2022 | 332-0 v GranadaReal Betis 2-0 Granada | Spanish La Liga |
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