| 1 | Sat 14 Aug 2021 | 3 1-1 v MallorcaMallorca 1-1 Real Betis | Spanish La Liga |
| 2 | Fri 20 Aug 2021 | 31-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 3 | Thu 16 Sep 2021 | 34-3 v CelticReal Betis 4-3 Celtic | UEFA Europa League Group G |
| 4 | Sun 19 Sep 2021 | 3 2-2 v EspanyolReal Betis 2-2 Espanyol | Spanish La Liga |
| 5 | Thu 23 Sep 2021 | 33-1 v OsasunaOsasuna 1-3 Real Betis | Spanish La Liga |
| 6 | Sun 26 Sep 2021 | 32-0 v GetafeReal Betis 2-0 Getafe | Spanish La Liga |
| 7 | Sun 3 Oct 2021 | 3 0-2 v VillarrealVillarreal 2-0 Real Betis | Spanish La Liga |
| 8 | Mon 18 Oct 2021 | 3 1-0 v AlavésAlavés 0-1 Real Betis | Spanish La Liga |
| 9 | Thu 21 Oct 2021 | 31-1 v Bayer 04 LeverkusenReal Betis 1-1 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 10 | Sun 24 Oct 2021 | 3 3-2 v Rayo VallecanoReal Betis 3-2 Rayo Vallecano | Spanish La Liga |
| 11 | Sun 31 Oct 2021 | 30-3 v Atlético MadridAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 12 | Sun 7 Nov 2021 | 30-2 v SevillaReal Betis 0-2 Sevilla | Spanish La Liga |
| 13 | Sun 21 Nov 2021 | 33-0 v ElcheElche 0-3 Real Betis | Spanish La Liga |
| 14 | Thu 25 Nov 2021 | 32-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 15 | Sun 28 Nov 2021 | 33-1 v LevanteReal Betis 3-1 Levante | Spanish La Liga |
| 16 | Thu 9 Dec 2021 | 32-3 v CelticCeltic 3-2 Real Betis | UEFA Europa League Group G |
| 17 | Sun 19 Dec 2021 | 32-3 v Athletic BilbaoAthletic Bilbao 3-2 Real Betis | Spanish La Liga |
| 18 | Sun 9 Jan 2022 | 31-1 v Rayo VallecanoRayo Vallecano 1-1 Real Betis | Spanish La Liga |
| 19 | Tue 18 Jan 2022 | 3 4-0 v AlavésReal Betis 4-0 Alavés | Spanish La Liga |
| 20 | Fri 21 Jan 2022 | 34-1 v EspanyolEspanyol 1-4 Real Betis | Spanish La Liga |
| 21 | Sun 13 Feb 2022 | 34-2 v LevanteLevante 2-4 Real Betis | Spanish La Liga |
| 22 | Thu 17 Feb 2022 | 33-2 v Zenit St PetersburgZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 23 | Sun 20 Feb 2022 | 32-1 v MallorcaReal Betis 2-1 Mallorca | Spanish La Liga |
| 24 | Thu 24 Feb 2022 | 30-0 v Zenit St PetersburgReal Betis 0-0 Zenit St Petersburg | UEFA Europa League Round of 32 |
| 25 | Wed 9 Mar 2022 | 31-2 v Eintracht FrankfurtReal Betis 1-2 Eintracht Frankfurt | UEFA Europa League Round of 16 |
| 26 | Sun 13 Mar 2022 | 31-0 v Athletic BilbaoReal Betis 1-0 Athletic Bilbao | Spanish La Liga |
| 27 | Tue 10 May 2022 | 33-0 v ValenciaValencia 0-3 Real Betis | Spanish La Liga |
| 28 | Sun 15 May 2022 | 32-0 v GranadaReal Betis 2-0 Granada | Spanish La Liga |
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