| 1 | Sun 20 Sep 2020 | 8 2-0 v Real ValladolidReal Betis 2-0 Real Valladolid | Spanish La Liga |
| 2 | Sat 26 Sep 2020 | 82-3 v Real MadridReal Betis 2-3 Real Madrid | Spanish La Liga |
| 3 | Tue 29 Sep 2020 | 8 0-3 v GetafeGetafe 3-0 Real Betis | Spanish La Liga |
| 4 | Sat 3 Oct 2020 | 82-0 v ValenciaValencia 0-2 Real Betis | Spanish La Liga |
| 5 | Sun 18 Oct 2020 | 80-3 v Real SociedadReal Betis 0-3 Real Sociedad | Spanish La Liga |
| 6 | Sat 24 Oct 2020 | 80-2 v Atlético MadridAtlético Madrid 2-0 Real Betis | Spanish La Liga |
| 7 | Sun 1 Nov 2020 | 8 3-1 v ElcheReal Betis 3-1 Elche | Spanish La Liga |
| 8 | Mon 30 Nov 2020 | 80-2 v EibarReal Betis 0-2 Eibar | Spanish La Liga |
| 9 | Sun 6 Dec 2020 | 82-0 v OsasunaOsasuna 0-2 Real Betis | Spanish La Liga |
| 10 | Sun 13 Dec 2020 | 81-1 v VillarrealReal Betis 1-1 Villarreal | Spanish La Liga |
| 11 | Sun 20 Dec 2020 | 8 0-2 v GranadaGranada 2-0 Real Betis | Spanish La Liga |
| 12 | Wed 23 Dec 2020 | 81-0 v CádizReal Betis 1-0 Cádiz | Spanish La Liga |
| 13 | Tue 29 Dec 2020 | 83-4 v LevanteLevante 4-3 Real Betis | Spanish La Liga |
| 14 | Sat 2 Jan 2021 | 81-1 v SevillaReal Betis 1-1 Sevilla | Spanish La Liga |
| 15 | Mon 11 Jan 2021 | 82-0 v HuescaHuesca 0-2 Real Betis | Spanish La Liga |
| 16 | Wed 20 Jan 2021 | 82-1 v Celta VigoReal Betis 2-1 Celta Vigo | Spanish La Liga |
| 17 | Sat 23 Jan 2021 | 82-2 v Real SociedadReal Sociedad 2-2 Real Betis | Spanish La Liga |
| 18 | Mon 1 Feb 2021 | 81-0 v OsasunaReal Betis 1-0 Osasuna | Spanish La Liga |
| 19 | Sun 7 Feb 2021 | 82-3 v BarcelonaReal Betis 2-3 Barcelona | Spanish La Liga |
| 20 | Sun 14 Feb 2021 | 82-1 v VillarrealVillarreal 1-2 Real Betis | Spanish La Liga |
| 21 | Fri 19 Feb 2021 | 81-0 v GetafeReal Betis 1-0 Getafe | Spanish La Liga |
| 22 | Mon 8 Mar 2021 | 83-2 v AlavésReal Betis 3-2 Alavés | Spanish La Liga |
| 23 | Sun 14 Mar 2021 | 80-1 v SevillaSevilla 1-0 Real Betis | Spanish La Liga |
| 24 | Fri 19 Mar 2021 | 82-0 v LevanteReal Betis 2-0 Levante | Spanish La Liga |
| 25 | Sun 4 Apr 2021 | 81-1 v ElcheElche 1-1 Real Betis | Spanish La Liga |
| 26 | Sun 11 Apr 2021 | 81-1 v Atlético MadridReal Betis 1-1 Atlético Madrid | Spanish La Liga |
| 27 | Sun 18 Apr 2021 | 82-2 v ValenciaReal Betis 2-2 Valencia | Spanish La Liga |
| 28 | Wed 21 Apr 2021 | 8 0-0 v Athletic BilbaoReal Betis 0-0 Athletic Bilbao | Spanish La Liga |
| 29 | Sun 2 May 2021 | 8 1-1 v Real ValladolidReal Valladolid 1-1 Real Betis | Spanish La Liga |
| 30 | Thu 13 May 2021 | 81-1 v EibarEibar 1-1 Real Betis | Spanish La Liga |
| 31 | Sun 16 May 2021 | 81-0 v HuescaReal Betis 1-0 Huesca | Spanish La Liga |
| 32 | Sat 22 May 2021 | 83-2 v Celta VigoCelta Vigo 2-3 Real Betis | Spanish La Liga |
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