| 1 | Sat 26 Sep 2020 | 162-3 v Real MadridReal Betis 2-3 Real Madrid | Spanish La Liga |
| 2 | Tue 29 Sep 2020 | 160-3 v GetafeGetafe 3-0 Real Betis | Spanish La Liga |
| 3 | Sun 18 Oct 2020 | 160-3 v Real SociedadReal Betis 0-3 Real Sociedad | Spanish La Liga |
| 4 | Sat 24 Oct 2020 | 160-2 v Atlético MadridAtlético Madrid 2-0 Real Betis | Spanish La Liga |
| 5 | Sat 7 Nov 2020 | 162-5 v BarcelonaBarcelona 5-2 Real Betis | Spanish La Liga |
| 6 | Mon 23 Nov 2020 | 160-4 v Athletic BilbaoAthletic Bilbao 4-0 Real Betis | Spanish La Liga |
| 7 | Mon 30 Nov 2020 | 160-2 v EibarReal Betis 0-2 Eibar | Spanish La Liga |
| 8 | Sun 6 Dec 2020 | 16 2-0 v OsasunaOsasuna 0-2 Real Betis | Spanish La Liga |
| 9 | Sun 20 Dec 2020 | 160-2 v GranadaGranada 2-0 Real Betis | Spanish La Liga |
| 10 | Wed 23 Dec 2020 | 161-0 v CádizReal Betis 1-0 Cádiz | Spanish La Liga |
| 11 | Sat 2 Jan 2021 | 161-1 v SevillaReal Betis 1-1 Sevilla | Spanish La Liga |
| 12 | Mon 11 Jan 2021 | 162-0 v HuescaHuesca 0-2 Real Betis | Spanish La Liga |
| 13 | Wed 20 Jan 2021 | 162-1 v Celta VigoReal Betis 2-1 Celta Vigo | Spanish La Liga |
| 14 | Sat 23 Jan 2021 | 162-2 v Real SociedadReal Sociedad 2-2 Real Betis | Spanish La Liga |
| 15 | Mon 1 Feb 2021 | 161-0 v OsasunaReal Betis 1-0 Osasuna | Spanish La Liga |
| 16 | Sun 7 Feb 2021 | 162-3 v BarcelonaReal Betis 2-3 Barcelona | Spanish La Liga |
| 17 | Sun 14 Feb 2021 | 162-1 v VillarrealVillarreal 1-2 Real Betis | Spanish La Liga |
| 18 | Fri 19 Feb 2021 | 161-0 v GetafeReal Betis 1-0 Getafe | Spanish La Liga |
| 19 | Sun 28 Feb 2021 | 161-0 v CádizCádiz 0-1 Real Betis | Spanish La Liga |
| 20 | Sun 4 Apr 2021 | 161-1 v ElcheElche 1-1 Real Betis | Spanish La Liga |
| 21 | Wed 21 Apr 2021 | 160-0 v Athletic BilbaoReal Betis 0-0 Athletic Bilbao | Spanish La Liga |
| 22 | Sat 24 Apr 2021 | 16 0-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
| 23 | Sun 2 May 2021 | 161-1 v Real ValladolidReal Valladolid 1-1 Real Betis | Spanish La Liga |
| 24 | Thu 13 May 2021 | 161-1 v EibarEibar 1-1 Real Betis | Spanish La Liga |
| 25 | Sun 16 May 2021 | 161-0 v HuescaReal Betis 1-0 Huesca | Spanish La Liga |
| 26 | Sat 22 May 2021 | 163-2 v Celta VigoCelta Vigo 2-3 Real Betis | Spanish La Liga |
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