| 1 | Sat 7 Aug 2021 | 32-3 v Stoke CityStoke City 3-2 Reading | Sky Bet Championship |
| 2 | Tue 10 Aug 2021 | 30-3 v Swansea CityReading 0-3 Swansea City | Carabao Cup First Round |
| 3 | Sat 21 Aug 2021 | 31-2 v Coventry CityCoventry City 2-1 Reading | Sky Bet Championship |
| 4 | Sat 28 Aug 2021 | 30-4 v Huddersfield TownHuddersfield Town 4-0 Reading | Sky Bet Championship |
| 5 | Sat 11 Sep 2021 | 33-3 v Queens Park RangersReading 3-3 Queens Park Rangers | Sky Bet Championship |
| 6 | Tue 14 Sep 2021 | 33-1 v Peterborough UnitedReading 3-1 Peterborough United | Sky Bet Championship |
| 7 | Sat 18 Sep 2021 | 32-1 v FulhamFulham 1-2 Reading | Sky Bet Championship |
| 8 | Tue 2 Nov 2021 | 30-1 v MillwallMillwall 1-0 Reading | Sky Bet Championship |
| 9 | Sat 6 Nov 2021 | 3 2-1 v Birmingham CityBirmingham City 1-2 Reading | Sky Bet Championship |
| 10 | Sat 20 Nov 2021 | 31-1 v Nottingham ForestReading 1-1 Nottingham Forest | Sky Bet Championship |
| 11 | Tue 23 Nov 2021 | 30-1 v Sheffield UnitedReading 0-1 Sheffield United | Sky Bet Championship |
| 12 | Sat 27 Nov 2021 | 33-2 v Swansea CitySwansea City 2-3 Reading | Sky Bet Championship |
| 13 | Sat 4 Dec 2021 | 31-1 v Hull CityReading 1-1 Hull City | Sky Bet Championship |
| 14 | Sat 11 Dec 2021 | 30-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Reading | Sky Bet Championship |
| 15 | Mon 3 Jan 2022 | 32-2 v Derby CountyReading 2-2 Derby County | Sky Bet Championship |
| 16 | Sat 8 Jan 2022 | 3 1-2 v Kidderminster HarriersKidderminster Harriers 2-1 Reading | Emirates FA Cup Third Round |
| 17 | Tue 11 Jan 2022 | 30-7 v FulhamReading 0-7 Fulham | Sky Bet Championship |
| 18 | Sat 15 Jan 2022 | 31-2 v MiddlesbroughMiddlesbrough 2-1 Reading | Sky Bet Championship |
| 19 | Wed 19 Jan 2022 | 30-2 v Luton TownReading 0-2 Luton Town | Sky Bet Championship |
| 20 | Sat 22 Jan 2022 | 33-4 v Huddersfield TownReading 3-4 Huddersfield Town | Sky Bet Championship |
| 21 | Sat 29 Jan 2022 | 30-4 v Queens Park RangersQueens Park Rangers 4-0 Reading | Sky Bet Championship |
| 22 | Wed 9 Feb 2022 | 3 1-2 v Bristol CityBristol City 2-1 Reading | Sky Bet Championship |
| 23 | Sat 12 Feb 2022 | 3 2-3 v Coventry CityReading 2-3 Coventry City | Sky Bet Championship |
| 24 | Wed 16 Feb 2022 | 3 0-0 v Peterborough UnitedPeterborough United 0-0 Reading | Sky Bet Championship |
| 25 | Sat 19 Feb 2022 | 33-2 v Preston North EndPreston North End 2-3 Reading | Sky Bet Championship |
| 26 | Tue 22 Feb 2022 | 32-1 v Birmingham CityReading 2-1 Birmingham City | Sky Bet Championship |
| 27 | Sat 5 Mar 2022 | 30-1 v MillwallReading 0-1 Millwall | Sky Bet Championship |
| 28 | Tue 15 Mar 2022 | 31-1 v AFC BournemouthAFC Bournemouth 1-1 Reading | Sky Bet Championship |
| 29 | Sat 19 Mar 2022 | 31-0 v Blackburn RoversReading 1-0 Blackburn Rovers | Sky Bet Championship |
| 30 | Sat 2 Apr 2022 | 31-1 v BarnsleyBarnsley 1-1 Reading | Sky Bet Championship |
| 31 | Tue 5 Apr 2022 | 32-1 v Stoke CityReading 2-1 Stoke City | Sky Bet Championship |
| 32 | Sat 9 Apr 2022 | 31-2 v Cardiff CityReading 1-2 Cardiff City | Sky Bet Championship |
| 33 | Fri 15 Apr 2022 | 32-1 v Sheffield UnitedSheffield United 1-2 Reading | Sky Bet Championship |
| 34 | Sat 7 May 2022 | 30-1 v Luton TownLuton Town 1-0 Reading | Sky Bet Championship |
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