| 1 | Wed 29 Sep 2021 | 240-1 v Derby CountyDerby County 1-0 Reading | Sky Bet Championship |
| 2 | Sat 2 Oct 2021 | 241-0 v Cardiff CityCardiff City 0-1 Reading | Sky Bet Championship |
| 3 | Sat 16 Oct 2021 | 241-0 v BarnsleyReading 1-0 Barnsley | Sky Bet Championship |
| 4 | Wed 20 Oct 2021 | 242-3 v BlackpoolReading 2-3 Blackpool | Sky Bet Championship |
| 5 | Sat 23 Oct 2021 | 240-2 v Blackburn RoversBlackburn Rovers 2-0 Reading | Sky Bet Championship |
| 6 | Sat 30 Oct 2021 | 240-2 v AFC BournemouthReading 0-2 AFC Bournemouth | Sky Bet Championship |
| 7 | Tue 2 Nov 2021 | 240-1 v MillwallMillwall 1-0 Reading | Sky Bet Championship |
| 8 | Sat 6 Nov 2021 | 242-1 v Birmingham CityBirmingham City 1-2 Reading | Sky Bet Championship |
| 9 | Sat 20 Nov 2021 | 241-1 v Nottingham ForestReading 1-1 Nottingham Forest | Sky Bet Championship |
| 10 | Tue 23 Nov 2021 | 240-1 v Sheffield UnitedReading 0-1 Sheffield United | Sky Bet Championship |
| 11 | Sat 27 Nov 2021 | 243-2 v Swansea CitySwansea City 2-3 Reading | Sky Bet Championship |
| 12 | Sat 4 Dec 2021 | 241-1 v Hull CityReading 1-1 Hull City | Sky Bet Championship |
| 13 | Sat 11 Dec 2021 | 240-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Reading | Sky Bet Championship |
| 14 | Mon 3 Jan 2022 | 242-2 v Derby CountyReading 2-2 Derby County | Sky Bet Championship |
| 15 | Tue 11 Jan 2022 | 240-7 v FulhamReading 0-7 Fulham | Sky Bet Championship |
| 16 | Sat 5 Mar 2022 | 240-1 v MillwallReading 0-1 Millwall | Sky Bet Championship |
| 17 | Sat 12 Mar 2022 | 240-4 v Nottingham ForestNottingham Forest 4-0 Reading | Sky Bet Championship |
| 18 | Tue 5 Apr 2022 | 242-1 v Stoke CityReading 2-1 Stoke City | Sky Bet Championship |
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