| 1 | Sat 7 Aug 2021 | 6 2-3 v Stoke CityStoke City 3-2 Reading | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 62-1 v Preston North EndReading 2-1 Preston North End | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 62-3 v Bristol CityReading 2-3 Bristol City | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 61-2 v Coventry CityCoventry City 2-1 Reading | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 6 0-4 v Huddersfield TownHuddersfield Town 4-0 Reading | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 63-3 v Queens Park RangersReading 3-3 Queens Park Rangers | Sky Bet Championship |
| 7 | Tue 14 Sep 2021 | 63-1 v Peterborough UnitedReading 3-1 Peterborough United | Sky Bet Championship |
| 8 | Sat 2 Oct 2021 | 61-0 v Cardiff CityCardiff City 0-1 Reading | Sky Bet Championship |
| 9 | Sat 16 Oct 2021 | 61-0 v BarnsleyReading 1-0 Barnsley | Sky Bet Championship |
| 10 | Wed 20 Oct 2021 | 62-3 v BlackpoolReading 2-3 Blackpool | Sky Bet Championship |
| 11 | Sat 23 Oct 2021 | 60-2 v Blackburn RoversBlackburn Rovers 2-0 Reading | Sky Bet Championship |
| 12 | Sat 30 Oct 2021 | 60-2 v AFC BournemouthReading 0-2 AFC Bournemouth | Sky Bet Championship |
| 13 | Tue 2 Nov 2021 | 60-1 v MillwallMillwall 1-0 Reading | Sky Bet Championship |
| 14 | Sat 6 Nov 2021 | 62-1 v Birmingham CityBirmingham City 1-2 Reading | Sky Bet Championship |
| 15 | Sat 20 Nov 2021 | 6 1-1 v Nottingham ForestReading 1-1 Nottingham Forest | Sky Bet Championship |
| 16 | Tue 23 Nov 2021 | 60-1 v Sheffield UnitedReading 0-1 Sheffield United | Sky Bet Championship |
| 17 | Sat 11 Dec 2021 | 60-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Reading | Sky Bet Championship |
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