| 1 | Fri 22 Aug | 490-6 v Bayern MunichBayern Munich 6-0 RB Leipzig | German Bundesliga |
| 2 | Sat 30 Aug | 492-0 v 1 FC HeidenheimRB Leipzig 2-0 1 FC Heidenheim | German Bundesliga |
| 3 | Sat 13 Sep | 491-0 v Mainz 05Mainz 05 0-1 RB Leipzig | German Bundesliga |
| 4 | Sat 20 Sep | 493-1 v 1 FC KölnRB Leipzig 3-1 1 FC Köln | German Bundesliga |
| 5 | Sat 27 Sep | 49 1-0 v VfL WolfsburgVfL Wolfsburg 0-1 RB Leipzig | German Bundesliga |
| 6 | Sat 4 Oct | 491-1 v Borussia DortmundBorussia Dortmund 1-1 RB Leipzig | German Bundesliga |
| 7 | Sat 18 Oct | 49 2-1 v Hamburger SVRB Leipzig 2-1 Hamburger SV | German Bundesliga |
| 8 | Sat 25 Oct | 496-0 v FC AugsburgFC Augsburg 0-6 RB Leipzig | German Bundesliga |
| 9 | Sat 1 Nov | 493-1 v VfB StuttgartRB Leipzig 3-1 VfB Stuttgart | German Bundesliga |
| 10 | Sat 8 Nov | 491-3 v TSG HoffenheimTSG Hoffenheim 3-1 RB Leipzig | German Bundesliga |
| 11 | Sun 23 Nov | 492-0 v Werder BremenRB Leipzig 2-0 Werder Bremen | German Bundesliga |
| 12 | Fri 28 Nov | 490-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-0 RB Leipzig | German Bundesliga |
| 13 | Sat 6 Dec | 496-0 v Eintracht FrankfurtRB Leipzig 6-0 Eintracht Frankfurt | German Bundesliga |
| 14 | Fri 12 Dec | 491-3 v Union BerlinUnion Berlin 3-1 RB Leipzig | German Bundesliga |
| 15 | Wed 14 Jan | 492-0 v SC FreiburgRB Leipzig 2-0 SC Freiburg | German Bundesliga |
| 16 | Sat 17 Jan | 491-5 v Bayern MunichRB Leipzig 1-5 Bayern Munich | German Bundesliga |
| 17 | Sat 24 Jan | 493-0 v 1 FC Heidenheim1 FC Heidenheim 0-3 RB Leipzig | German Bundesliga |
| 18 | Tue 27 Jan | 491-1 v FC St PauliFC St Pauli 1-1 RB Leipzig | German Bundesliga |
| 19 | Sat 31 Jan | 491-2 v Mainz 05RB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 20 | Sun 8 Feb | 492-1 v 1 FC Köln1 FC Köln 1-2 RB Leipzig | German Bundesliga |
| 21 | Sun 15 Feb | 492-2 v VfL WolfsburgRB Leipzig 2-2 VfL Wolfsburg | German Bundesliga |
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