| 1 | Sat 31 Aug | 53-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-3 RB Leipzig | German Bundesliga |
| 2 | Sat 14 Sep | 50-0 v 1 FC Union BerlinRB Leipzig 0-0 1 FC Union Berlin | German Bundesliga |
| 3 | Sat 28 Sep | 54-0 v FC AugsburgRB Leipzig 4-0 FC Augsburg | German Bundesliga |
| 4 | Wed 23 Oct | 50-1 v LiverpoolRB Leipzig 0-1 Liverpool | UEFA Champions League Matchday 3 |
| 5 | Sat 26 Oct | 53-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg | German Bundesliga |
| 6 | Sat 2 Nov | 51-2 v Borussia DortmundBorussia Dortmund 2-1 RB Leipzig | German Bundesliga |
| 7 | Tue 5 Nov | 51-3 v CelticCeltic 3-1 RB Leipzig | UEFA Champions League Matchday 4 |
| 8 | Sat 9 Nov | 50-0 v Borussia MönchengladbachRB Leipzig 0-0 Borussia Mönchengladbach | German Bundesliga |
| 9 | Sun 15 Dec | 52-1 v Eintracht FrankfurtRB Leipzig 2-1 Eintracht Frankfurt | German Bundesliga |
| 10 | Wed 15 Jan | 5 1-2 v VfB StuttgartVfB Stuttgart 2-1 RB Leipzig | German Bundesliga |
| 11 | Wed 22 Jan | 52-1 v Sporting CPRB Leipzig 2-1 Sporting CP | UEFA Champions League Matchday 7 |
| 12 | Sat 25 Jan | 52-2 v Bayer 04 LeverkusenRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Wed 29 Jan | 50-1 v Sturm GrazSturm Graz 1-0 RB Leipzig | UEFA Champions League Matchday 8 |
| 14 | Sat 1 Feb | 50-0 v 1 FC Union Berlin1 FC Union Berlin 0-0 RB Leipzig | German Bundesliga |
| 15 | Sun 9 Feb | 52-0 v FC St PauliRB Leipzig 2-0 FC St Pauli | German Bundesliga |
| 16 | Sun 23 Feb | 52-2 v 1 FC HeidenheimRB Leipzig 2-2 1 FC Heidenheim | German Bundesliga |
| 17 | Sat 1 Mar | 51-2 v Mainz 05RB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 18 | Sat 8 Mar | 50-0 v SC FreiburgSC Freiburg 0-0 RB Leipzig | German Bundesliga |
| 19 | Sat 15 Mar | 52-0 v Borussia DortmundRB Leipzig 2-0 Borussia Dortmund | German Bundesliga |
| 20 | Sat 29 Mar | 50-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-0 RB Leipzig | German Bundesliga |
| 21 | Fri 11 Apr | 5 3-2 v VfL WolfsburgVfL Wolfsburg 2-3 RB Leipzig | German Bundesliga |
| 22 | Sat 19 Apr | 51-1 v Holstein KielRB Leipzig 1-1 Holstein Kiel | German Bundesliga |
| 23 | Sat 26 Apr | 5 0-4 v Eintracht FrankfurtEintracht Frankfurt 4-0 RB Leipzig | German Bundesliga |
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