| 1 | Sun 7 Aug 2022 | 41-1 v VfB StuttgartVfB Stuttgart 1-1 RB Leipzig | German Bundesliga |
| 2 | Sat 13 Aug 2022 | 42-2 v 1 FC KölnRB Leipzig 2-2 1 FC Köln | German Bundesliga |
| 3 | Sat 20 Aug 2022 | 41-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 RB Leipzig | German Bundesliga |
| 4 | Sat 27 Aug 2022 | 42-0 v VfL WolfsburgRB Leipzig 2-0 VfL Wolfsburg | German Bundesliga |
| 5 | Sat 3 Sep 2022 | 40-4 v Eintracht FrankfurtEintracht Frankfurt 4-0 RB Leipzig | German Bundesliga |
| 6 | Tue 6 Sep 2022 | 41-4 v Shakhtar DonetskRB Leipzig 1-4 Shakhtar Donetsk | UEFA Champions League Group F |
| 7 | Sat 10 Sep 2022 | 43-0 v Borussia DortmundRB Leipzig 3-0 Borussia Dortmund | German Bundesliga |
| 8 | Wed 14 Sep 2022 | 40-2 v Real MadridReal Madrid 2-0 RB Leipzig | UEFA Champions League Group F |
| 9 | Sat 17 Sep 2022 | 40-3 v Borussia MönchengladbachBorussia Mönchengladbach 3-0 RB Leipzig | German Bundesliga |
| 10 | Sat 1 Oct 2022 | 44-0 v VfL BochumRB Leipzig 4-0 VfL Bochum | German Bundesliga |
| 11 | Wed 5 Oct 2022 | 43-1 v CelticRB Leipzig 3-1 Celtic | UEFA Champions League Group F |
| 12 | Sat 8 Oct 2022 | 41-1 v Mainz 05Mainz 05 1-1 RB Leipzig | German Bundesliga |
| 13 | Tue 11 Oct 2022 | 42-0 v CelticCeltic 0-2 RB Leipzig | UEFA Champions League Group F |
| 14 | Sat 15 Oct 2022 | 43-2 v Hertha BerlinRB Leipzig 3-2 Hertha Berlin | German Bundesliga |
| 15 | Sat 22 Oct 2022 | 43-3 v FC AugsburgFC Augsburg 3-3 RB Leipzig | German Bundesliga |
| 16 | Tue 25 Oct 2022 | 43-2 v Real MadridRB Leipzig 3-2 Real Madrid | UEFA Champions League Group F |
| 17 | Sat 29 Oct 2022 | 42-0 v Bayer 04 LeverkusenRB Leipzig 2-0 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Wed 2 Nov 2022 | 44-0 v Shakhtar DonetskShakhtar Donetsk 0-4 RB Leipzig | UEFA Champions League Group F |
| 19 | Sat 5 Nov 2022 | 43-1 v 1899 Hoffenheim1899 Hoffenheim 1-3 RB Leipzig | German Bundesliga |
| 20 | Wed 9 Nov 2022 | 43-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg | German Bundesliga |
| 21 | Sat 12 Nov 2022 | 42-1 v Werder BremenWerder Bremen 1-2 RB Leipzig | German Bundesliga |
| 22 | Fri 20 Jan 2023 | 41-1 v Bayern MunichRB Leipzig 1-1 Bayern Munich | German Bundesliga |
| 23 | Tue 24 Jan 2023 | 46-1 v FC Schalke 04FC Schalke 04 1-6 RB Leipzig | German Bundesliga |
| 24 | Fri 27 Jan 2023 | 42-1 v VfB StuttgartRB Leipzig 2-1 VfB Stuttgart | German Bundesliga |
| 25 | Sat 4 Feb 2023 | 40-0 v 1 FC Köln1 FC Köln 0-0 RB Leipzig | German Bundesliga |
| 26 | Sat 18 Feb 2023 | 43-0 v VfL WolfsburgVfL Wolfsburg 0-3 RB Leipzig | German Bundesliga |
| 27 | Wed 22 Feb 2023 | 41-1 v Manchester CityRB Leipzig 1-1 Manchester City | UEFA Champions League Round of 16 |
| 28 | Sat 25 Feb 2023 | 4 2-1 v Eintracht FrankfurtRB Leipzig 2-1 Eintracht Frankfurt | German Bundesliga |
| 29 | Fri 3 Mar 2023 | 41-2 v Borussia DortmundBorussia Dortmund 2-1 RB Leipzig | German Bundesliga |
| 30 | Sat 11 Mar 2023 | 43-0 v Borussia MönchengladbachRB Leipzig 3-0 Borussia Mönchengladbach | German Bundesliga |
| 31 | Tue 14 Mar 2023 | 40-7 v Manchester CityManchester City 7-0 RB Leipzig | UEFA Champions League Round of 16 |
| 32 | Sat 18 Mar 2023 | 40-1 v VfL BochumVfL Bochum 1-0 RB Leipzig | German Bundesliga |
| 33 | Sat 1 Apr 2023 | 4 0-3 v Mainz 05RB Leipzig 0-3 Mainz 05 | German Bundesliga |
| 34 | Sat 8 Apr 2023 | 41-0 v Hertha BerlinHertha Berlin 0-1 RB Leipzig | German Bundesliga |
| 35 | Sat 15 Apr 2023 | 43-2 v FC AugsburgRB Leipzig 3-2 FC Augsburg | German Bundesliga |
| 36 | Sun 23 Apr 2023 | 40-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-0 RB Leipzig | German Bundesliga |
| 37 | Sat 29 Apr 2023 | 41-0 v 1899 HoffenheimRB Leipzig 1-0 1899 Hoffenheim | German Bundesliga |
| 38 | Sat 6 May 2023 | 41-0 v SC FreiburgSC Freiburg 0-1 RB Leipzig | German Bundesliga |
| 39 | Sun 14 May 2023 | 42-1 v Werder BremenRB Leipzig 2-1 Werder Bremen | German Bundesliga |
| 40 | Sat 20 May 2023 | 43-1 v Bayern MunichBayern Munich 1-3 RB Leipzig | German Bundesliga |
| 41 | Sat 27 May 2023 | 44-2 v FC Schalke 04RB Leipzig 4-2 FC Schalke 04 | German Bundesliga |
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