| 1 | Sun 20 Sep 2020 | 33-1 v Mainz 05RB Leipzig 3-1 Mainz 05 | German Bundesliga |
| 2 | Sat 26 Sep 2020 | 31-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-1 RB Leipzig | German Bundesliga |
| 3 | Sat 3 Oct 2020 | 34-0 v FC Schalke 04RB Leipzig 4-0 FC Schalke 04 | German Bundesliga |
| 4 | Sat 17 Oct 2020 | 32-0 v FC AugsburgFC Augsburg 0-2 RB Leipzig | German Bundesliga |
| 5 | Tue 20 Oct 2020 | 32-0 v İstanbul BaşakşehirRB Leipzig 2-0 İstanbul Başakşehir | UEFA Champions League Group H |
| 6 | Sat 24 Oct 2020 | 32-1 v Hertha BerlinRB Leipzig 2-1 Hertha Berlin | German Bundesliga |
| 7 | Wed 28 Oct 2020 | 30-5 v Manchester UnitedManchester United 5-0 RB Leipzig | UEFA Champions League Group H |
| 8 | Sat 31 Oct 2020 | 30-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-0 RB Leipzig | German Bundesliga |
| 9 | Wed 4 Nov 2020 | 32-1 v Paris St GermainRB Leipzig 2-1 Paris St Germain | UEFA Champions League Group H |
| 10 | Sat 21 Nov 2020 | 31-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 RB Leipzig | German Bundesliga |
| 11 | Tue 24 Nov 2020 | 30-1 v Paris St GermainParis St Germain 1-0 RB Leipzig | UEFA Champions League Group H |
| 12 | Sat 28 Nov 2020 | 32-1 v Arminia BielefeldRB Leipzig 2-1 Arminia Bielefeld | German Bundesliga |
| 13 | Wed 2 Dec 2020 | 34-3 v İstanbul Başakşehirİstanbul Başakşehir 3-4 RB Leipzig | UEFA Champions League Group H |
| 14 | Sat 5 Dec 2020 | 33-3 v Bayern MunichBayern Munich 3-3 RB Leipzig | German Bundesliga |
| 15 | Tue 8 Dec 2020 | 33-2 v Manchester UnitedRB Leipzig 3-2 Manchester United | UEFA Champions League Group H |
| 16 | Wed 16 Dec 2020 | 31-0 v 1899 Hoffenheim1899 Hoffenheim 0-1 RB Leipzig | German Bundesliga |
| 17 | Sat 19 Dec 2020 | 30-0 v 1. FC KölnRB Leipzig 0-0 1. FC Köln | German Bundesliga |
| 18 | Sat 2 Jan 2021 | 31-0 v VfB StuttgartVfB Stuttgart 0-1 RB Leipzig | German Bundesliga |
| 19 | Sat 9 Jan 2021 | 31-3 v Borussia DortmundRB Leipzig 1-3 Borussia Dortmund | German Bundesliga |
| 20 | Sat 16 Jan 2021 | 3 2-2 v VfL WolfsburgVfL Wolfsburg 2-2 RB Leipzig | German Bundesliga |
| 21 | Wed 20 Jan 2021 | 3 1-0 v 1. FC Union BerlinRB Leipzig 1-0 1. FC Union Berlin | German Bundesliga |
| 22 | Sat 23 Jan 2021 | 32-3 v Mainz 05Mainz 05 3-2 RB Leipzig | German Bundesliga |
| 23 | Sat 30 Jan 2021 | 31-0 v Bayer 04 LeverkusenRB Leipzig 1-0 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Sat 6 Feb 2021 | 33-0 v FC Schalke 04FC Schalke 04 0-3 RB Leipzig | German Bundesliga |
| 25 | Fri 12 Feb 2021 | 32-1 v FC AugsburgRB Leipzig 2-1 FC Augsburg | German Bundesliga |
| 26 | Tue 16 Feb 2021 | 3 0-2 v LiverpoolRB Leipzig 0-2 Liverpool | UEFA Champions League Round of 16 |
| 27 | Sun 21 Feb 2021 | 33-0 v Hertha BerlinHertha Berlin 0-3 RB Leipzig | German Bundesliga |
| 28 | Fri 16 Apr 2021 | 30-0 v 1899 HoffenheimRB Leipzig 0-0 1899 Hoffenheim | German Bundesliga |
| 29 | Tue 20 Apr 2021 | 31-2 v 1. FC Köln1. FC Köln 2-1 RB Leipzig | German Bundesliga |
| 30 | Sun 25 Apr 2021 | 32-0 v VfB StuttgartRB Leipzig 2-0 VfB Stuttgart | German Bundesliga |
| 31 | Sat 8 May 2021 | 32-3 v Borussia DortmundBorussia Dortmund 3-2 RB Leipzig | German Bundesliga |
| 32 | Sun 16 May 2021 | 32-2 v VfL WolfsburgRB Leipzig 2-2 VfL Wolfsburg | German Bundesliga |
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