| 1 | Sat 10 Aug | 15-1 v RKC WaalwijkPSV Eindhoven 5-1 RKC Waalwijk | Dutch Eredivisie |
| 2 | Sun 18 Aug | 13-1 v Heracles AlmeloHeracles Almelo 1-3 PSV Eindhoven | Dutch Eredivisie |
| 3 | Sat 24 Aug | 17-1 v Almere CityAlmere City 1-7 PSV Eindhoven | Dutch Eredivisie |
| 4 | Sun 1 Sep | 13-0 v Go Ahead EaglesPSV Eindhoven 3-0 Go Ahead Eagles | Dutch Eredivisie |
| 5 | Sat 14 Sep | 12-0 v NEC NijmegenPSV Eindhoven 2-0 NEC Nijmegen | Dutch Eredivisie |
| 6 | Sun 22 Sep | 13-1 v Fortuna SittardFortuna Sittard 1-3 PSV Eindhoven | Dutch Eredivisie |
| 7 | Sat 28 Sep | 12-0 v Willem IIWillem II 0-2 PSV Eindhoven | Dutch Eredivisie |
| 8 | Tue 1 Oct | 11-1 v Sporting CPPSV Eindhoven 1-1 Sporting CP | UEFA Champions League Matchday 2 |
| 9 | Sat 5 Oct | 12-1 v Sparta RotterdamPSV Eindhoven 2-1 Sparta Rotterdam | Dutch Eredivisie |
| 10 | Sat 19 Oct | 12-1 v AZ AlkmaarAZ Alkmaar 1-2 PSV Eindhoven | Dutch Eredivisie |
| 11 | Tue 22 Oct | 1 1-1 v Paris St GermainParis St Germain 1-1 PSV Eindhoven | UEFA Champions League Matchday 3 |
| 12 | Sat 26 Oct | 16-0 v PEC ZwollePSV Eindhoven 6-0 PEC Zwolle | Dutch Eredivisie |
| 13 | Sat 2 Nov | 12-3 v AjaxAjax 3-2 PSV Eindhoven | Dutch Eredivisie |
| 14 | Tue 5 Nov | 14-0 v GironaPSV Eindhoven 4-0 Girona | UEFA Champions League Matchday 4 |
| 15 | Sat 9 Nov | 13-0 v NAC BredaNAC Breda 0-3 PSV Eindhoven | Dutch Eredivisie |
| 16 | Sat 23 Nov | 15-0 v FC GroningenPSV Eindhoven 5-0 FC Groningen | Dutch Eredivisie |
| 17 | Wed 27 Nov | 13-2 v Shakhtar DonetskPSV Eindhoven 3-2 Shakhtar Donetsk | UEFA Champions League Matchday 5 |
| 18 | Sun 1 Dec | 15-2 v FC UtrechtFC Utrecht 2-5 PSV Eindhoven | Dutch Eredivisie |
| 19 | Fri 6 Dec | 16-1 v FC TwentePSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 20 | Tue 10 Dec | 10-1 v BrestBrest 1-0 PSV Eindhoven | UEFA Champions League Matchday 6 |
| 21 | Sat 14 Dec | 10-1 v sc Heerenveensc Heerenveen 1-0 PSV Eindhoven | Dutch Eredivisie |
| 22 | Sun 22 Dec | 13-0 v FeyenoordPSV Eindhoven 3-0 Feyenoord | Dutch Eredivisie |
| 23 | Sat 11 Jan | 12-2 v AZ AlkmaarPSV Eindhoven 2-2 AZ Alkmaar | Dutch Eredivisie |
| 24 | Sat 18 Jan | 11-3 v PEC ZwollePEC Zwolle 3-1 PSV Eindhoven | Dutch Eredivisie |
| 25 | Tue 21 Jan | 13-2 v Crvena ZvezdaCrvena Zvezda 2-3 PSV Eindhoven | UEFA Champions League Matchday 7 |
| 26 | Sat 25 Jan | 13-2 v NAC BredaPSV Eindhoven 3-2 NAC Breda | Dutch Eredivisie |
| 27 | Wed 29 Jan | 13-2 v LiverpoolPSV Eindhoven 3-2 Liverpool | UEFA Champions League Matchday 8 |
| 28 | Sat 1 Feb | 13-3 v NEC NijmegenNEC Nijmegen 3-3 PSV Eindhoven | Dutch Eredivisie |
| 29 | Sat 8 Feb | 11-1 v Willem IIPSV Eindhoven 1-1 Willem II | Dutch Eredivisie |
| 30 | Tue 11 Feb | 11-2 v JuventusJuventus 2-1 PSV Eindhoven | UEFA Champions League Play-off Knockout Round |
| 31 | Sat 15 Feb | 12-2 v FC UtrechtPSV Eindhoven 2-2 FC Utrecht | Dutch Eredivisie |
| 32 | Wed 19 Feb | 13-1 v JuventusPSV Eindhoven 3-1 Juventus | UEFA Champions League Play-off Knockout Round |
| 33 | Sat 1 Mar | 12-3 v Go Ahead EaglesGo Ahead Eagles 3-2 PSV Eindhoven | Dutch Eredivisie |
| 34 | Tue 4 Mar | 11-7 v ArsenalPSV Eindhoven 1-7 Arsenal | UEFA Champions League Round of 16 |
| 35 | Sat 8 Mar | 12-1 v sc HeerenveenPSV Eindhoven 2-1 sc Heerenveen | Dutch Eredivisie |
| 36 | Wed 12 Mar | 12-2 v ArsenalArsenal 2-2 PSV Eindhoven | UEFA Champions League Round of 16 |
| 37 | Sat 15 Mar | 13-0 v RKC WaalwijkRKC Waalwijk 0-3 PSV Eindhoven | Dutch Eredivisie |
| 38 | Sun 30 Mar | 10-2 v AjaxPSV Eindhoven 0-2 Ajax | Dutch Eredivisie |
| 39 | Sat 5 Apr | 13-1 v FC GroningenFC Groningen 1-3 PSV Eindhoven | Dutch Eredivisie |
| 40 | Sat 12 Apr | 15-0 v Almere CityPSV Eindhoven 5-0 Almere City | Dutch Eredivisie |
| 41 | Thu 24 Apr | 13-1 v FC TwenteFC Twente 1-3 PSV Eindhoven | Dutch Eredivisie |
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