| 1 | Sat 28 Sep | 5 2-0 v Willem IIWillem II 0-2 PSV Eindhoven | Dutch Eredivisie |
| 2 | Sat 5 Oct | 52-1 v Sparta RotterdamPSV Eindhoven 2-1 Sparta Rotterdam | Dutch Eredivisie |
| 3 | Sat 19 Oct | 52-1 v AZ AlkmaarAZ Alkmaar 1-2 PSV Eindhoven | Dutch Eredivisie |
| 4 | Sat 26 Oct | 56-0 v PEC ZwollePSV Eindhoven 6-0 PEC Zwolle | Dutch Eredivisie |
| 5 | Sat 2 Nov | 52-3 v AjaxAjax 3-2 PSV Eindhoven | Dutch Eredivisie |
| 6 | Sat 9 Nov | 53-0 v NAC BredaNAC Breda 0-3 PSV Eindhoven | Dutch Eredivisie |
| 7 | Sat 23 Nov | 55-0 v FC GroningenPSV Eindhoven 5-0 FC Groningen | Dutch Eredivisie |
| 8 | Sun 1 Dec | 55-2 v FC UtrechtFC Utrecht 2-5 PSV Eindhoven | Dutch Eredivisie |
| 9 | Fri 6 Dec | 56-1 v FC TwentePSV Eindhoven 6-1 FC Twente | Dutch Eredivisie |
| 10 | Sat 14 Dec | 50-1 v sc Heerenveensc Heerenveen 1-0 PSV Eindhoven | Dutch Eredivisie |
| 11 | Sun 22 Dec | 53-0 v FeyenoordPSV Eindhoven 3-0 Feyenoord | Dutch Eredivisie |
| 12 | Sat 11 Jan | 52-2 v AZ AlkmaarPSV Eindhoven 2-2 AZ Alkmaar | Dutch Eredivisie |
| 13 | Sat 18 Jan | 51-3 v PEC ZwollePEC Zwolle 3-1 PSV Eindhoven | Dutch Eredivisie |
| 14 | Sat 25 Jan | 5 3-2 v NAC BredaPSV Eindhoven 3-2 NAC Breda | Dutch Eredivisie |
| 15 | Sat 1 Feb | 53-3 v NEC NijmegenNEC Nijmegen 3-3 PSV Eindhoven | Dutch Eredivisie |
| 16 | Sat 8 Feb | 51-1 v Willem IIPSV Eindhoven 1-1 Willem II | Dutch Eredivisie |
| 17 | Tue 11 Feb | 51-2 v JuventusJuventus 2-1 PSV Eindhoven | UEFA Champions League Play-off Knockout Round |
| 18 | Sat 15 Feb | 52-2 v FC UtrechtPSV Eindhoven 2-2 FC Utrecht | Dutch Eredivisie |
| 19 | Wed 19 Feb | 53-1 v JuventusPSV Eindhoven 3-1 Juventus | UEFA Champions League Play-off Knockout Round |
| 20 | Sat 1 Mar | 52-3 v Go Ahead EaglesGo Ahead Eagles 3-2 PSV Eindhoven | Dutch Eredivisie |
| 21 | Tue 4 Mar | 51-7 v ArsenalPSV Eindhoven 1-7 Arsenal | UEFA Champions League Round of 16 |
| 22 | Sat 8 Mar | 5 2-1 v sc HeerenveenPSV Eindhoven 2-1 sc Heerenveen | Dutch Eredivisie |
| 23 | Wed 12 Mar | 52-2 v ArsenalArsenal 2-2 PSV Eindhoven | UEFA Champions League Round of 16 |
| 24 | Sat 15 Mar | 53-0 v RKC WaalwijkRKC Waalwijk 0-3 PSV Eindhoven | Dutch Eredivisie |
| 25 | Sun 30 Mar | 50-2 v AjaxPSV Eindhoven 0-2 Ajax | Dutch Eredivisie |
| 26 | Sat 5 Apr | 53-1 v FC GroningenFC Groningen 1-3 PSV Eindhoven | Dutch Eredivisie |
| 27 | Thu 24 Apr | 53-1 v FC TwenteFC Twente 1-3 PSV Eindhoven | Dutch Eredivisie |
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