| 1 | Wed 28 Jul 2021 | 32-1 v GalatasarayGalatasaray 1-2 PSV Eindhoven | UEFA Champions League Second Qualifying Round |
| 2 | Tue 3 Aug 2021 | 33-0 v FC MidtjyllandPSV Eindhoven 3-0 FC Midtjylland | UEFA Champions League Third Qualifying Round |
| 3 | Tue 10 Aug 2021 | 31-0 v FC MidtjyllandFC Midtjylland 0-1 PSV Eindhoven | UEFA Champions League Third Qualifying Round |
| 4 | Sat 14 Aug 2021 | 32-0 v Heracles AlmeloHeracles Almelo 0-2 PSV Eindhoven | Dutch Eredivisie |
| 5 | Tue 24 Aug 2021 | 30-0 v BenficaPSV Eindhoven 0-0 Benfica | UEFA Champions League Qualifying Play-off Round |
| 6 | Sat 28 Aug 2021 | 35-2 v FC GroningenPSV Eindhoven 5-2 FC Groningen | Dutch Eredivisie |
| 7 | Sat 11 Sep 2021 | 33-0 v AZ AlkmaarAZ Alkmaar 0-3 PSV Eindhoven | Dutch Eredivisie |
| 8 | Thu 16 Sep 2021 | 32-2 v Real SociedadPSV Eindhoven 2-2 Real Sociedad | UEFA Europa League Group B |
| 9 | Sun 19 Sep 2021 | 30-4 v FeyenoordPSV Eindhoven 0-4 Feyenoord | Dutch Eredivisie |
| 10 | Wed 22 Sep 2021 | 32-1 v Go Ahead EaglesGo Ahead Eagles 1-2 PSV Eindhoven | Dutch Eredivisie |
| 11 | Sat 16 Oct 2021 | 33-1 v PEC ZwollePSV Eindhoven 3-1 PEC Zwolle | Dutch Eredivisie |
| 12 | Sun 24 Oct 2021 | 30-5 v AjaxAjax 5-0 PSV Eindhoven | Dutch Eredivisie |
| 13 | Sat 30 Oct 2021 | 35-2 v FC TwentePSV Eindhoven 5-2 FC Twente | Dutch Eredivisie |
| 14 | Thu 4 Nov 2021 | 30-0 v MonacoMonaco 0-0 PSV Eindhoven | UEFA Europa League Group B |
| 15 | Sun 7 Nov 2021 | 34-1 v Fortuna SittardFortuna Sittard 1-4 PSV Eindhoven | Dutch Eredivisie |
| 16 | Sat 4 Dec 2021 | 34-1 v FC UtrechtPSV Eindhoven 4-1 FC Utrecht | Dutch Eredivisie |
| 17 | Thu 9 Dec 2021 | 30-3 v Real SociedadReal Sociedad 3-0 PSV Eindhoven | UEFA Europa League Group B |
| 18 | Sun 12 Dec 2021 | 32-1 v NEC NijmegenNEC Nijmegen 1-2 PSV Eindhoven | Dutch Eredivisie |
| 19 | Sun 19 Dec 2021 | 34-1 v RKC WaalwijkRKC Waalwijk 1-4 PSV Eindhoven | Dutch Eredivisie |
| 20 | Sun 16 Jan 2022 | 3 1-0 v FC GroningenFC Groningen 0-1 PSV Eindhoven | Dutch Eredivisie |
| 21 | Sun 23 Jan 2022 | 31-2 v AjaxPSV Eindhoven 1-2 Ajax | Dutch Eredivisie |
| 22 | Sat 5 Feb 2022 | 3 1-2 v AZ AlkmaarPSV Eindhoven 1-2 AZ Alkmaar | Dutch Eredivisie |
| 23 | Sat 12 Feb 2022 | 35-0 v VitesseVitesse 0-5 PSV Eindhoven | Dutch Eredivisie |
| 24 | Thu 17 Feb 2022 | 3 1-0 v Maccabi Tel-AvivPSV Eindhoven 1-0 Maccabi Tel-Aviv | UEFA Europa Conference League |
| 25 | Sun 20 Feb 2022 | 33-1 v sc HeerenveenPSV Eindhoven 3-1 sc Heerenveen | Dutch Eredivisie |
| 26 | Thu 24 Feb 2022 | 31-1 v Maccabi Tel-AvivMaccabi Tel-Aviv 1-1 PSV Eindhoven | UEFA Europa Conference League |
| 27 | Sun 27 Feb 2022 | 3 2-1 v Sparta RotterdamSparta Rotterdam 1-2 PSV Eindhoven | Dutch Eredivisie |
| 28 | Sun 6 Mar 2022 | 33-1 v Heracles AlmeloPSV Eindhoven 3-1 Heracles Almelo | Dutch Eredivisie |
| 29 | Thu 10 Mar 2022 | 3 4-4 v FC CopenhagenPSV Eindhoven 4-4 FC Copenhagen | UEFA Europa Conference League Round of 16 |
| 30 | Sun 13 Mar 2022 | 3 1-0 v FC UtrechtFC Utrecht 0-1 PSV Eindhoven | Dutch Eredivisie |
| 31 | Thu 17 Mar 2022 | 34-0 v FC CopenhagenFC Copenhagen 0-4 PSV Eindhoven | UEFA Europa Conference League Round of 16 |
| 32 | Sun 20 Mar 2022 | 35-0 v Fortuna SittardPSV Eindhoven 5-0 Fortuna Sittard | Dutch Eredivisie |
| 33 | Sat 2 Apr 2022 | 33-3 v FC TwenteFC Twente 3-3 PSV Eindhoven | Dutch Eredivisie |
| 34 | Thu 7 Apr 2022 | 30-0 v Leicester CityLeicester City 0-0 PSV Eindhoven | UEFA Europa Conference League Quarter Final |
| 35 | Sun 10 Apr 2022 | 32-0 v RKC WaalwijkPSV Eindhoven 2-0 RKC Waalwijk | Dutch Eredivisie |
| 36 | Thu 14 Apr 2022 | 31-2 v Leicester CityPSV Eindhoven 1-2 Leicester City | UEFA Europa Conference League Quarter Final |
| 37 | Sun 1 May 2022 | 34-2 v Willem IIPSV Eindhoven 4-2 Willem II | Dutch Eredivisie |
| 38 | Sun 8 May 2022 | 32-2 v FeyenoordFeyenoord 2-2 PSV Eindhoven | Dutch Eredivisie |
| 39 | Wed 11 May 2022 | 33-2 v NEC NijmegenPSV Eindhoven 3-2 NEC Nijmegen | Dutch Eredivisie |
| 40 | Sun 15 May 2022 | 32-1 v PEC ZwollePEC Zwolle 1-2 PSV Eindhoven | Dutch Eredivisie |
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