| 1 | Sat 7 Aug 2021 | 191-4 v Hull CityPreston North End 1-4 Hull City | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 191-2 v ReadingReading 2-1 Preston North End | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 190-1 v Huddersfield TownHuddersfield Town 1-0 Preston North End | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 191-0 v Peterborough UnitedPreston North End 1-0 Peterborough United | Sky Bet Championship |
| 5 | Tue 24 Aug 2021 | 194-2 v MorecambeMorecambe 2-4 Preston North End | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 193-1 v Swansea CityPreston North End 3-1 Swansea City | Sky Bet Championship |
| 7 | Sat 11 Sep 2021 | 190-0 v Bristol CityBristol City 0-0 Preston North End | Sky Bet Championship |
| 8 | Tue 14 Sep 2021 | 19 2-2 v Sheffield UnitedSheffield United 2-2 Preston North End | Sky Bet Championship |
| 9 | Sat 18 Sep 2021 | 191-1 v West Bromwich AlbionPreston North End 1-1 West Bromwich Albion | Sky Bet Championship |
| 10 | Tue 21 Sep 2021 | 194-1 v Cheltenham TownPreston North End 4-1 Cheltenham Town | Carabao Cup Third Round |
| 11 | Sat 25 Sep 2021 | 190-0 v Birmingham CityBirmingham City 0-0 Preston North End | Sky Bet Championship |
| 12 | Tue 28 Sep 2021 | 19 1-1 v Stoke CityPreston North End 1-1 Stoke City | Sky Bet Championship |
| 13 | Sat 2 Oct 2021 | 192-3 v Queens Park RangersQueens Park Rangers 3-2 Preston North End | Sky Bet Championship |
| 14 | Sat 16 Oct 2021 | 190-0 v Derby CountyPreston North End 0-0 Derby County | Sky Bet Championship |
| 15 | Wed 20 Oct 2021 | 192-1 v Coventry CityPreston North End 2-1 Coventry City | Sky Bet Championship |
| 16 | Sat 23 Oct 2021 | 190-2 v BlackpoolBlackpool 2-0 Preston North End | Sky Bet Championship |
| 17 | Wed 27 Oct 2021 | 190-2 v LiverpoolPreston North End 0-2 Liverpool | Carabao Cup Round of 16 |
| 18 | Sat 30 Oct 2021 | 192-0 v Luton TownPreston North End 2-0 Luton Town | Sky Bet Championship |
| 19 | Wed 3 Nov 2021 | 192-1 v AFC BournemouthAFC Bournemouth 1-2 Preston North End | Sky Bet Championship |
| 20 | Sat 6 Nov 2021 | 190-3 v Nottingham ForestNottingham Forest 3-0 Preston North End | Sky Bet Championship |
| 21 | Sat 20 Nov 2021 | 191-2 v Cardiff CityPreston North End 1-2 Cardiff City | Sky Bet Championship |
| 22 | Tue 23 Nov 2021 | 192-1 v MiddlesbroughMiddlesbrough 1-2 Preston North End | Sky Bet Championship |
| 23 | Sat 27 Nov 2021 | 191-1 v FulhamPreston North End 1-1 Fulham | Sky Bet Championship |
| 24 | Sat 4 Dec 2021 | 19 0-1 v Blackburn RoversBlackburn Rovers 1-0 Preston North End | Sky Bet Championship |
| 25 | Sat 11 Dec 2021 | 192-1 v BarnsleyPreston North End 2-1 Barnsley | Sky Bet Championship |
| 26 | Mon 3 Jan 2022 | 192-1 v Stoke CityStoke City 1-2 Preston North End | Sky Bet Championship |
| 27 | Sun 9 Jan 2022 | 191-2 v Cardiff CityCardiff City 2-1 Preston North End | Emirates FA Cup Third Round |
| 28 | Sat 15 Jan 2022 | 191-1 v Birmingham CityPreston North End 1-1 Birmingham City | Sky Bet Championship |
| 29 | Tue 18 Jan 2022 | 192-2 v Sheffield UnitedPreston North End 2-2 Sheffield United | Sky Bet Championship |
| 30 | Sat 22 Jan 2022 | 190-1 v Swansea CitySwansea City 1-0 Preston North End | Sky Bet Championship |
| 31 | Wed 26 Jan 2022 | 19 2-0 v West Bromwich AlbionWest Bromwich Albion 0-2 Preston North End | Sky Bet Championship |
| 32 | Sat 29 Jan 2022 | 192-2 v Bristol CityPreston North End 2-2 Bristol City | Sky Bet Championship |
| 33 | Tue 1 Feb 2022 | 190-0 v MillwallMillwall 0-0 Preston North End | Sky Bet Championship |
| 34 | Sat 5 Feb 2022 | 191-0 v Hull CityHull City 0-1 Preston North End | Sky Bet Championship |
| 35 | Wed 9 Feb 2022 | 190-0 v Huddersfield TownPreston North End 0-0 Huddersfield Town | Sky Bet Championship |
| 36 | Sat 12 Feb 2022 | 191-0 v Peterborough UnitedPeterborough United 0-1 Preston North End | Sky Bet Championship |
| 37 | Sat 19 Feb 2022 | 192-3 v ReadingPreston North End 2-3 Reading | Sky Bet Championship |
| 38 | Tue 22 Feb 2022 | 190-0 v Nottingham ForestPreston North End 0-0 Nottingham Forest | Sky Bet Championship |
| 39 | Sat 26 Feb 2022 | 191-1 v Coventry CityCoventry City 1-1 Preston North End | Sky Bet Championship |
| 40 | Sat 5 Mar 2022 | 192-1 v AFC BournemouthPreston North End 2-1 AFC Bournemouth | Sky Bet Championship |
| 41 | Sat 12 Mar 2022 | 190-0 v Cardiff CityCardiff City 0-0 Preston North End | Sky Bet Championship |
| 42 | Wed 16 Mar 2022 | 190-4 v Luton TownLuton Town 4-0 Preston North End | Sky Bet Championship |
| 43 | Sat 2 Apr 2022 | 190-1 v Derby CountyDerby County 1-0 Preston North End | Sky Bet Championship |
| 44 | Tue 5 Apr 2022 | 191-0 v BlackpoolPreston North End 1-0 Blackpool | Sky Bet Championship |
| 45 | Sat 9 Apr 2022 | 192-1 v Queens Park RangersPreston North End 2-1 Queens Park Rangers | Sky Bet Championship |
| 46 | Mon 25 Apr 2022 | 191-4 v Blackburn RoversPreston North End 1-4 Blackburn Rovers | Sky Bet Championship |
| 47 | Sat 30 Apr 2022 | 193-1 v BarnsleyBarnsley 1-3 Preston North End | Sky Bet Championship |
| 48 | Sat 7 May 2022 | 194-1 v MiddlesbroughPreston North End 4-1 Middlesbrough | Sky Bet Championship |
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