| 1 | Tue 31 Aug 2021 | 22-3 v Bolton WanderersBolton Wanderers 3-2 Port Vale | Papa John’s Trophy |
| 2 | Sat 11 Sep 2021 | 22-1 v Swindon TownSwindon Town 1-2 Port Vale | Sky Bet League Two |
| 3 | Sat 18 Sep 2021 | 22-0 v Harrogate TownPort Vale 2-0 Harrogate Town | Sky Bet League Two |
| 4 | Sat 25 Sep 2021 | 21-0 v Scunthorpe UnitedScunthorpe United 0-1 Port Vale | Sky Bet League Two |
| 5 | Sat 2 Oct 2021 | 23-2 v Leyton OrientPort Vale 3-2 Leyton Orient | Sky Bet League Two |
| 6 | Tue 5 Oct 2021 | 21-0 v RochdalePort Vale 1-0 Rochdale | Papa John’s Trophy |
| 7 | Sat 9 Oct 2021 | 2 3-4 v Sutton UnitedSutton United 4-3 Port Vale | Sky Bet League Two |
| 8 | Sat 16 Oct 2021 | 23-1 v BarrowPort Vale 3-1 Barrow | Sky Bet League Two |
| 9 | Tue 19 Oct 2021 | 21-1 v Mansfield TownMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 10 | Sat 23 Oct 2021 | 2 3-0 v Colchester UnitedPort Vale 3-0 Colchester United | Sky Bet League Two |
| 11 | Sat 30 Oct 2021 | 24-1 v Crawley TownCrawley Town 1-4 Port Vale | Sky Bet League Two |
| 12 | Sat 6 Nov 2021 | 2 5-1 v Accrington StanleyPort Vale 5-1 Accrington Stanley | Emirates FA Cup First Round |
| 13 | Sat 13 Nov 2021 | 21-1 v Bradford CityPort Vale 1-1 Bradford City | Sky Bet League Two |
| 14 | Sat 20 Nov 2021 | 22-3 v Oldham AthleticOldham Athletic 3-2 Port Vale | Sky Bet League Two |
| 15 | Tue 23 Nov 2021 | 2 0-1 v WalsallPort Vale 0-1 Walsall | Sky Bet League Two |
| 16 | Sat 27 Nov 2021 | 2 2-0 v Hartlepool UnitedPort Vale 2-0 Hartlepool United | Sky Bet League Two |
| 17 | Sat 4 Dec 2021 | 22-1 v Burton AlbionBurton Albion 1-2 Port Vale | Emirates FA Cup Second Round |
| 18 | Tue 7 Dec 2021 | 22-1 v Bristol RoversBristol Rovers 1-2 Port Vale | Sky Bet League Two |
| 19 | Sat 11 Dec 2021 | 2 1-2 v Newport CountyNewport County 2-1 Port Vale | Sky Bet League Two |
| 20 | Sat 8 Jan 2022 | 21-4 v BrentfordPort Vale 1-4 Brentford | Emirates FA Cup Third Round |
| 21 | Tue 18 Jan 2022 | 2 0-1 v Salford CityPort Vale 0-1 Salford City | Sky Bet League Two |
| 22 | Sat 22 Jan 2022 | 20-0 v Leyton OrientLeyton Orient 0-0 Port Vale | Sky Bet League Two |
| 23 | Sat 19 Feb 2022 | 21-1 v Tranmere RoversTranmere Rovers 1-1 Port Vale | Sky Bet League Two |
| 24 | Tue 22 Feb 2022 | 21-1 v RochdaleRochdale 1-1 Port Vale | Sky Bet League Two |
| 25 | Sat 26 Feb 2022 | 22-0 v StevenagePort Vale 2-0 Stevenage | Sky Bet League Two |
| 26 | Tue 1 Mar 2022 | 21-1 v Harrogate TownHarrogate Town 1-1 Port Vale | Sky Bet League Two |
| 27 | Mon 2 May 2022 | 21-2 v Newport CountyPort Vale 1-2 Newport County | Sky Bet League Two |
| 28 | Sat 7 May 2022 | 21-0 v Exeter CityExeter City 0-1 Port Vale | Sky Bet League Two |
| 29 | Sun 15 May 2022 | 21-2 v Swindon TownSwindon Town 2-1 Port Vale | Sky Bet League Two Play-off Semi Final |
| 30 | Thu 19 May 2022 | 21-0 v Swindon TownPort Vale 1-0 Swindon Town | Sky Bet League Two Play-off Semi Final |
| 31 | Sat 28 May 2022 | 23-0 v Mansfield TownMansfield Town 0-3 Port Vale | Sky Bet League Two Play-off Final |
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