| 1 | Sat 11 Sep 2021 | 183-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 2 | Sat 18 Sep 2021 | 181-0 v AFC WimbledonAFC Wimbledon 0-1 Plymouth Argyle | Sky Bet League One |
| 3 | Tue 21 Sep 2021 | 182-2 v PortsmouthPortsmouth 2-2 Plymouth Argyle | Sky Bet League One |
| 4 | Sat 25 Sep 2021 | 182-1 v Doncaster RoversPlymouth Argyle 2-1 Doncaster Rovers | Sky Bet League One |
| 5 | Tue 28 Sep 2021 | 181-1 v Crewe AlexandraPlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 6 | Sat 2 Oct 2021 | 182-2 v Lincoln CityLincoln City 2-2 Plymouth Argyle | Sky Bet League One |
| 7 | Sat 9 Oct 2021 | 182-1 v Burton AlbionPlymouth Argyle 2-1 Burton Albion | Sky Bet League One |
| 8 | Tue 12 Oct 2021 | 181-3 v Swindon TownPlymouth Argyle 1-3 Swindon Town | Papa John’s Trophy |
| 9 | Sat 23 Oct 2021 | 181-1 v MorecambeMorecambe 1-1 Plymouth Argyle | Sky Bet League One |
| 10 | Sun 7 Nov 2021 | 180-0 v Sheffield WednesdaySheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 11 | Sat 13 Nov 2021 | 184-1 v Accrington StanleyAccrington Stanley 1-4 Plymouth Argyle | Sky Bet League One |
| 12 | Tue 16 Nov 2021 | 183-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 13 | Sat 27 Nov 2021 | 181-2 v Wigan AthleticPlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
| 14 | Sat 18 Dec 2021 | 181-0 v Charlton AthleticPlymouth Argyle 1-0 Charlton Athletic | Sky Bet League One |
| 15 | Sun 26 Dec 2021 | 182-0 v Cheltenham TownCheltenham Town 0-2 Plymouth Argyle | Sky Bet League One |
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