| 1 | Sat 28 Aug 2021 | 40-1 v Willem IIWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 2 | Sun 19 Sep 2021 | 40-1 v Go Ahead EaglesGo Ahead Eagles 1-0 PEC Zwolle | Dutch Eredivisie |
| 3 | Wed 22 Sep 2021 | 41-1 v Sparta RotterdamPEC Zwolle 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sat 25 Sep 2021 | 41-5 v FC UtrechtFC Utrecht 5-1 PEC Zwolle | Dutch Eredivisie |
| 5 | Sat 2 Oct 2021 | 4 0-1 v sc HeerenveenPEC Zwolle 0-1 sc Heerenveen | Dutch Eredivisie |
| 6 | Sat 16 Oct 2021 | 41-3 v PSV EindhovenPSV Eindhoven 3-1 PEC Zwolle | Dutch Eredivisie |
| 7 | Sat 23 Oct 2021 | 41-0 v Heracles AlmeloPEC Zwolle 1-0 Heracles Almelo | Dutch Eredivisie |
| 8 | Sat 30 Oct 2021 | 42-3 v AZ AlkmaarAZ Alkmaar 3-2 PEC Zwolle | Dutch Eredivisie |
| 9 | Sun 21 Nov 2021 | 40-4 v FeyenoordFeyenoord 4-0 PEC Zwolle | Dutch Eredivisie |
| 10 | Sat 27 Nov 2021 | 40-0 v RKC WaalwijkPEC Zwolle 0-0 RKC Waalwijk | Dutch Eredivisie |
| 11 | Fri 3 Dec 2021 | 4 1-1 v FC GroningenFC Groningen 1-1 PEC Zwolle | Dutch Eredivisie |
| 12 | Sat 11 Dec 2021 | 4 0-1 v Fortuna SittardPEC Zwolle 0-1 Fortuna Sittard | Dutch Eredivisie |
| 13 | Sat 18 Dec 2021 | 41-3 v FC TwentePEC Zwolle 1-3 FC Twente | Dutch Eredivisie |
| 14 | Tue 21 Dec 2021 | 40-1 v VitesseVitesse 1-0 PEC Zwolle | Dutch Eredivisie |
| 15 | Fri 14 Jan 2022 | 42-0 v Willem IIPEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 16 | Sat 22 Jan 2022 | 41-0 v sc Heerenveensc Heerenveen 0-1 PEC Zwolle | Dutch Eredivisie |
| 17 | Sat 5 Feb 2022 | 4 1-1 v NEC NijmegenPEC Zwolle 1-1 NEC Nijmegen | Dutch Eredivisie |
| 18 | Sun 20 Feb 2022 | 41-1 v FC GroningenPEC Zwolle 1-1 FC Groningen | Dutch Eredivisie |
| 19 | Sat 26 Feb 2022 | 40-2 v Heracles AlmeloHeracles Almelo 2-0 PEC Zwolle | Dutch Eredivisie |
| 20 | Sun 6 Mar 2022 | 41-0 v Fortuna SittardFortuna Sittard 0-1 PEC Zwolle | Dutch Eredivisie |
| 21 | Sun 13 Mar 2022 | 4 1-2 v FeyenoordPEC Zwolle 1-2 Feyenoord | Dutch Eredivisie |
| 22 | Sun 3 Apr 2022 | 40-1 v Go Ahead EaglesPEC Zwolle 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 23 | Sun 10 Apr 2022 | 42-1 v AZ AlkmaarPEC Zwolle 2-1 AZ Alkmaar | Dutch Eredivisie |
| 24 | Sat 23 Apr 2022 | 42-0 v RKC WaalwijkRKC Waalwijk 0-2 PEC Zwolle | Dutch Eredivisie |
| 25 | Sat 30 Apr 2022 | 40-3 v AjaxAjax 3-0 PEC Zwolle | Dutch Eredivisie |
| 26 | Sat 7 May 2022 | 41-1 v FC UtrechtPEC Zwolle 1-1 FC Utrecht | Dutch Eredivisie |
| 27 | Wed 11 May 2022 | 40-2 v Sparta RotterdamSparta Rotterdam 2-0 PEC Zwolle | Dutch Eredivisie |
| 28 | Sun 15 May 2022 | 41-2 v PSV EindhovenPEC Zwolle 1-2 PSV Eindhoven | Dutch Eredivisie |
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