| 1 | Fri 20 Aug 2021 | 6 4-2 v BrestBrest 2-4 Paris St Germain | French Ligue 1 |
| 2 | Sun 29 Aug 2021 | 6 2-0 v ReimsReims 0-2 Paris St Germain | French Ligue 1 |
| 3 | Tue 28 Sep 2021 | 6 2-0 v Manchester CityParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 4 | Sun 3 Oct 2021 | 60-2 v RennesRennes 2-0 Paris St Germain | French Ligue 1 |
| 5 | Fri 15 Oct 2021 | 6 2-1 v AngersParis St Germain 2-1 Angers | French Ligue 1 |
| 6 | Tue 19 Oct 2021 | 63-2 v RB LeipzigParis St Germain 3-2 RB Leipzig | UEFA Champions League Group A |
| 7 | Sun 24 Oct 2021 | 60-0 v MarseilleMarseille 0-0 Paris St Germain | French Ligue 1 |
| 8 | Sat 20 Nov 2021 | 6 3-1 v NantesParis St Germain 3-1 Nantes | French Ligue 1 |
| 9 | Wed 1 Dec 2021 | 60-0 v NiceParis St Germain 0-0 Nice | French Ligue 1 |
| 10 | Sat 4 Dec 2021 | 6 1-1 v LensLens 1-1 Paris St Germain | French Ligue 1 |
| 11 | Tue 7 Dec 2021 | 64-1 v Club BruggeParis St Germain 4-1 Club Brugge | UEFA Champions League Group A |
| 12 | Sun 12 Dec 2021 | 6 2-0 v MonacoParis St Germain 2-0 Monaco | French Ligue 1 |
| 13 | Sun 9 Jan 2022 | 6 1-1 v LyonLyon 1-1 Paris St Germain | French Ligue 1 |
| 14 | Sat 15 Jan 2022 | 6 2-0 v BrestParis St Germain 2-0 Brest | French Ligue 1 |
| 15 | Sun 23 Jan 2022 | 64-0 v ReimsParis St Germain 4-0 Reims | French Ligue 1 |
| 16 | Sun 6 Feb 2022 | 65-1 v LilleLille 1-5 Paris St Germain | French Ligue 1 |
| 17 | Fri 11 Feb 2022 | 6 1-0 v RennesParis St Germain 1-0 Rennes | French Ligue 1 |
| 18 | Tue 15 Feb 2022 | 6 1-0 v Real MadridParis St Germain 1-0 Real Madrid | UEFA Champions League Round of 16 |
| 19 | Sat 19 Feb 2022 | 6 1-3 v NantesNantes 3-1 Paris St Germain | French Ligue 1 |
| 20 | Sat 5 Mar 2022 | 60-1 v NiceNice 1-0 Paris St Germain | French Ligue 1 |
| 21 | Wed 9 Mar 2022 | 61-3 v Real MadridReal Madrid 3-1 Paris St Germain | UEFA Champions League Round of 16 |
| 22 | Sun 20 Mar 2022 | 60-3 v MonacoMonaco 3-0 Paris St Germain | French Ligue 1 |
| 23 | Sat 9 Apr 2022 | 66-1 v ClermontClermont 1-6 Paris St Germain | French Ligue 1 |
| 24 | Sun 17 Apr 2022 | 6 2-1 v MarseilleParis St Germain 2-1 Marseille | French Ligue 1 |
| 25 | Sat 23 Apr 2022 | 6 1-1 v LensParis St Germain 1-1 Lens | French Ligue 1 |
| 26 | Fri 29 Apr 2022 | 63-3 v StrasbourgStrasbourg 3-3 Paris St Germain | French Ligue 1 |
| 27 | Sun 8 May 2022 | 62-2 v TroyesParis St Germain 2-2 Troyes | French Ligue 1 |
| 28 | Sat 14 May 2022 | 64-0 v MontpellierMontpellier 0-4 Paris St Germain | French Ligue 1 |
| 29 | Sat 21 May 2022 | 65-0 v MetzParis St Germain 5-0 Metz | French Ligue 1 |
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