| 1 | Sun 19 Sep 2021 | 502-1 v LyonParis St Germain 2-1 Lyon | French Ligue 1 |
| 2 | Tue 28 Sep 2021 | 502-0 v Manchester CityParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 3 | Sun 3 Oct 2021 | 50 0-2 v RennesRennes 2-0 Paris St Germain | French Ligue 1 |
| 4 | Fri 15 Oct 2021 | 502-1 v AngersParis St Germain 2-1 Angers | French Ligue 1 |
| 5 | Fri 29 Oct 2021 | 502-1 v LilleParis St Germain 2-1 Lille | French Ligue 1 |
| 6 | Wed 3 Nov 2021 | 50 2-2 v RB LeipzigRB Leipzig 2-2 Paris St Germain | UEFA Champions League Group A |
| 7 | Sun 28 Nov 2021 | 503-1 v Saint ÉtienneSaint Étienne 1-3 Paris St Germain | French Ligue 1 |
| 8 | Wed 1 Dec 2021 | 500-0 v NiceParis St Germain 0-0 Nice | French Ligue 1 |
| 9 | Tue 7 Dec 2021 | 504-1 v Club BruggeParis St Germain 4-1 Club Brugge | UEFA Champions League Group A |
| 10 | Sun 12 Dec 2021 | 502-0 v MonacoParis St Germain 2-0 Monaco | French Ligue 1 |
| 11 | Sat 15 Jan 2022 | 502-0 v BrestParis St Germain 2-0 Brest | French Ligue 1 |
| 12 | Sun 6 Feb 2022 | 505-1 v LilleLille 1-5 Paris St Germain | French Ligue 1 |
| 13 | Tue 15 Feb 2022 | 501-0 v Real MadridParis St Germain 1-0 Real Madrid | UEFA Champions League Round of 16 |
| 14 | Sat 26 Feb 2022 | 503-1 v Saint ÉtienneParis St Germain 3-1 Saint Étienne | French Ligue 1 |
| 15 | Wed 9 Mar 2022 | 50 1-3 v Real MadridReal Madrid 3-1 Paris St Germain | UEFA Champions League Round of 16 |
| 16 | Sun 20 Mar 2022 | 500-3 v MonacoMonaco 3-0 Paris St Germain | French Ligue 1 |
| 17 | Sun 3 Apr 2022 | 505-1 v LorientParis St Germain 5-1 Lorient | French Ligue 1 |
| 18 | Sat 9 Apr 2022 | 506-1 v ClermontClermont 1-6 Paris St Germain | French Ligue 1 |
| 19 | Sun 17 Apr 2022 | 50 2-1 v MarseilleParis St Germain 2-1 Marseille | French Ligue 1 |
| 20 | Fri 29 Apr 2022 | 50 3-3 v StrasbourgStrasbourg 3-3 Paris St Germain | French Ligue 1 |
| 21 | Sat 14 May 2022 | 504-0 v MontpellierMontpellier 0-4 Paris St Germain | French Ligue 1 |
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