| 1 | Sat 7 Aug 2021 | 41-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Wed 11 Aug 2021 | 41-1 v Burton AlbionBurton Albion 1-1 Oxford United | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 42-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 41-0 v Crewe AlexandraOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 41-2 v Bolton WanderersBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 6 | Sat 28 Aug 2021 | 43-1 v Lincoln CityOxford United 3-1 Lincoln City | Sky Bet League One |
| 7 | Sat 4 Sep 2021 | 41-3 v AFC WimbledonAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 8 | Sat 11 Sep 2021 | 40-0 v Wycombe WanderersOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 9 | Sat 18 Sep 2021 | 40-1 v Cheltenham TownCheltenham Town 1-0 Oxford United | Sky Bet League One |
| 10 | Sat 25 Sep 2021 | 41-1 v GillinghamOxford United 1-1 Gillingham | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 42-1 v Sheffield WednesdaySheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 12 | Tue 5 Oct 2021 | 41-2 v StevenageOxford United 1-2 Stevenage | Papa John’s Trophy |
| 13 | Sat 16 Oct 2021 | 41-3 v Plymouth ArgyleOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 14 | Tue 19 Oct 2021 | 42-0 v Shrewsbury TownOxford United 2-0 Shrewsbury Town | Sky Bet League One |
| 15 | Sat 23 Oct 2021 | 43-1 v Burton AlbionBurton Albion 1-3 Oxford United | Sky Bet League One |
| 16 | Sat 30 Oct 2021 | 43-1 v MorecambeOxford United 3-1 Morecambe | Sky Bet League One |
| 17 | Sun 7 Nov 2021 | 42-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 18 | Sat 13 Nov 2021 | 40-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 19 | Tue 16 Nov 2021 | 43-4 v Bristol RoversBristol Rovers 4-3 Oxford United | Emirates FA Cup First Round Replay |
| 20 | Tue 7 Dec 2021 | 42-1 v Doncaster RoversDoncaster Rovers 1-2 Oxford United | Sky Bet League One |
| 21 | Sat 11 Dec 2021 | 4 2-1 v Milton Keynes DonsMilton Keynes Dons 1-2 Oxford United | Sky Bet League One |
| 22 | Wed 29 Dec 2021 | 43-0 v AFC WimbledonOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 23 | Sat 1 Jan 2022 | 41-1 v Cheltenham TownOxford United 1-1 Cheltenham Town | Sky Bet League One |
| 24 | Sat 15 Jan 2022 | 40-2 v Wycombe WanderersWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 25 | Sat 22 Jan 2022 | 43-2 v Sheffield WednesdayOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
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