| 1 | Wed 11 Aug 2021 | 191-1 v Burton AlbionBurton Albion 1-1 Oxford United | Carabao Cup First Round |
| 2 | Tue 17 Aug 2021 | 191-0 v Crewe AlexandraOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 3 | Sat 21 Aug 2021 | 191-2 v Bolton WanderersBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 4 | Tue 24 Aug 2021 | 190-2 v Queens Park RangersQueens Park Rangers 2-0 Oxford United | Carabao Cup Second Round |
| 5 | Tue 31 Aug 2021 | 191-4 v Cambridge UnitedCambridge United 4-1 Oxford United | Papa John’s Trophy |
| 6 | Sat 11 Sep 2021 | 190-0 v Wycombe WanderersOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 190-1 v Cheltenham TownCheltenham Town 1-0 Oxford United | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 191-1 v GillinghamOxford United 1-1 Gillingham | Sky Bet League One |
| 9 | Sat 2 Oct 2021 | 192-1 v Sheffield WednesdaySheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 10 | Tue 5 Oct 2021 | 191-2 v StevenageOxford United 1-2 Stevenage | Papa John’s Trophy |
| 11 | Sat 16 Oct 2021 | 191-3 v Plymouth ArgyleOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 192-0 v Shrewsbury TownOxford United 2-0 Shrewsbury Town | Sky Bet League One |
| 13 | Sun 7 Nov 2021 | 192-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 14 | Sat 13 Nov 2021 | 190-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 15 | Tue 16 Nov 2021 | 193-4 v Bristol RoversBristol Rovers 4-3 Oxford United | Emirates FA Cup First Round Replay |
| 16 | Tue 23 Nov 2021 | 193-1 v Fleetwood TownOxford United 3-1 Fleetwood Town | Sky Bet League One |
| 17 | Sat 27 Nov 2021 | 190-0 v Rotherham UnitedOxford United 0-0 Rotherham United | Sky Bet League One |
| 18 | Sat 4 Dec 2021 | 191-1 v SunderlandSunderland 1-1 Oxford United | Sky Bet League One |
| 19 | Sat 18 Dec 2021 | 192-3 v Wigan AthleticOxford United 2-3 Wigan Athletic | Sky Bet League One |
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