| 1 | Sat 5 Feb 2022 | 43-2 v PortsmouthOxford United 3-2 Portsmouth | Sky Bet League One |
| 2 | Tue 8 Feb 2022 | 40-2 v Accrington StanleyAccrington Stanley 2-0 Oxford United | Sky Bet League One |
| 3 | Sat 19 Feb 2022 | 4 4-0 v Charlton AthleticCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 4 | Tue 22 Feb 2022 | 41-0 v Crewe AlexandraCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 5 | Tue 1 Mar 2022 | 42-3 v PortsmouthPortsmouth 3-2 Oxford United | Sky Bet League One |
| 6 | Sat 5 Mar 2022 | 44-1 v Burton AlbionOxford United 4-1 Burton Albion | Sky Bet League One |
| 7 | Sat 19 Mar 2022 | 41-1 v Ipswich TownOxford United 1-1 Ipswich Town | Sky Bet League One |
| 8 | Sat 2 Apr 2022 | 4 0-1 v Plymouth ArgylePlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 9 | Tue 5 Apr 2022 | 41-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 10 | Sat 9 Apr 2022 | 41-2 v SunderlandOxford United 1-2 Sunderland | Sky Bet League One |
| 11 | Fri 15 Apr 2022 | 43-2 v Fleetwood TownFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 12 | Tue 19 Apr 2022 | 41-0 v Milton Keynes DonsOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 23 Apr 2022 | 41-2 v Rotherham UnitedRotherham United 2-1 Oxford United | Sky Bet League One |
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