| 1 | Mon 23 Aug 2021 | 0-0 v Celta VigoOsasuna 0-0 Celta Vigo | Spanish La Liga |
| 2 | Sun 29 Aug 2021 | 163-2 v CádizCádiz 2-3 Osasuna | Spanish La Liga |
| 3 | Sun 12 Sep 2021 | 161-4 v ValenciaOsasuna 1-4 Valencia | Spanish La Liga |
| 4 | Sun 26 Sep 2021 | 163-2 v MallorcaMallorca 2-3 Osasuna | Spanish La Liga |
| 5 | Sat 2 Oct 2021 | 161-0 v Rayo VallecanoOsasuna 1-0 Rayo Vallecano | Spanish La Liga |
| 6 | Fri 22 Oct 2021 | 16 1-1 v GranadaOsasuna 1-1 Granada | Spanish La Liga |
| 7 | Sat 30 Oct 2021 | 160-2 v SevillaSevilla 2-0 Osasuna | Spanish La Liga |
| 8 | Sun 7 Nov 2021 | 160-2 v Real SociedadOsasuna 0-2 Real Sociedad | Spanish La Liga |
| 9 | Mon 29 Nov 2021 | 161-1 v ElcheOsasuna 1-1 Elche | Spanish La Liga |
| 10 | Sun 5 Dec 2021 | 160-0 v LevanteLevante 0-0 Osasuna | Spanish La Liga |
| 11 | Sun 12 Dec 2021 | 162-2 v BarcelonaOsasuna 2-2 Barcelona | Spanish La Liga |
| 12 | Mon 3 Jan 2022 | 16 1-3 v Athletic BilbaoOsasuna 1-3 Athletic Bilbao | Spanish La Liga |
| 13 | Sun 9 Jan 2022 | 162-0 v CádizOsasuna 2-0 Cádiz | Spanish La Liga |
| 14 | Wed 19 Jan 2022 | 160-2 v Celta VigoCelta Vigo 2-0 Osasuna | Spanish La Liga |
| 15 | Sat 5 Feb 2022 | 160-0 v SevillaOsasuna 0-0 Sevilla | Spanish La Liga |
| 16 | Sat 19 Feb 2022 | 160-3 v Atlético MadridOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 17 | Sun 27 Feb 2022 | 16 0-1 v Real SociedadReal Sociedad 1-0 Osasuna | Spanish La Liga |
| 18 | Sun 13 Mar 2022 | 160-4 v BarcelonaBarcelona 4-0 Osasuna | Spanish La Liga |
| 19 | Sun 3 Apr 2022 | 16 1-4 v Real BetisReal Betis 4-1 Osasuna | Spanish La Liga |
| 20 | Sun 10 Apr 2022 | 161-0 v AlavésOsasuna 1-0 Alavés | Spanish La Liga |
| 21 | Sat 16 Apr 2022 | 162-1 v ValenciaValencia 1-2 Osasuna | Spanish La Liga |
| 22 | Wed 20 Apr 2022 | 161-3 v Real MadridOsasuna 1-3 Real Madrid | Spanish La Liga |
| 23 | Sun 22 May 2022 | 160-2 v MallorcaOsasuna 0-2 Mallorca | Spanish La Liga |
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