| 1 | Sat 5 Feb 2022 | 24 1-0 v WalsallWalsall 0-1 Northampton Town | Sky Bet League Two |
| 2 | Tue 8 Feb 2022 | 241-0 v Newport CountyNorthampton Town 1-0 Newport County | Sky Bet League Two |
| 3 | Sat 12 Feb 2022 | 240-0 v Port ValePort Vale 0-0 Northampton Town | Sky Bet League Two |
| 4 | Sat 19 Feb 2022 | 243-0 v Colchester UnitedNorthampton Town 3-0 Colchester United | Sky Bet League Two |
| 5 | Sat 26 Feb 2022 | 240-1 v RochdaleRochdale 1-0 Northampton Town | Sky Bet League Two |
| 6 | Tue 1 Mar 2022 | 241-1 v WalsallNorthampton Town 1-1 Walsall | Sky Bet League Two |
| 7 | Sat 5 Mar 2022 | 243-2 v Tranmere RoversNorthampton Town 3-2 Tranmere Rovers | Sky Bet League Two |
| 8 | Sat 12 Mar 2022 | 241-2 v Carlisle UnitedCarlisle United 2-1 Northampton Town | Sky Bet League Two |
| 9 | Tue 15 Mar 2022 | 242-1 v StevenageStevenage 1-2 Northampton Town | Sky Bet League Two |
| 10 | Sat 19 Mar 2022 | 240-1 v Bristol RoversNorthampton Town 0-1 Bristol Rovers | Sky Bet League Two |
| 11 | Sat 26 Mar 2022 | 242-0 v Hartlepool UnitedNorthampton Town 2-0 Hartlepool United | Sky Bet League Two |
| 12 | Sat 2 Apr 2022 | 240-1 v Mansfield TownMansfield Town 1-0 Northampton Town | Sky Bet League Two |
| 13 | Sat 9 Apr 2022 | 240-0 v Bradford CityNorthampton Town 0-0 Bradford City | Sky Bet League Two |
| 14 | Fri 15 Apr 2022 | 242-0 v Oldham AthleticOldham Athletic 0-2 Northampton Town | Sky Bet League Two |
| 15 | Mon 18 Apr 2022 | 243-0 v Harrogate TownNorthampton Town 3-0 Harrogate Town | Sky Bet League Two |
| 16 | Sat 23 Apr 2022 | 244-2 v Leyton OrientLeyton Orient 2-4 Northampton Town | Sky Bet League Two |
| 17 | Sat 30 Apr 2022 | 241-1 v Exeter CityNorthampton Town 1-1 Exeter City | Sky Bet League Two |
| 18 | Sat 7 May 2022 | 243-1 v BarrowBarrow 1-3 Northampton Town | Sky Bet League Two |
| 19 | Sat 14 May 2022 | 241-2 v Mansfield TownMansfield Town 2-1 Northampton Town | Sky Bet League Two Play-off Semi Final |
| 20 | Wed 18 May 2022 | 240-1 v Mansfield TownNorthampton Town 0-1 Mansfield Town | Sky Bet League Two Play-off Semi Final |
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