| 1 | Sat 21 Aug 2021 | 5 0-2 v Aston VillaAston Villa 2-0 Newcastle United | Premier League |
| 2 | Sat 28 Aug 2021 | 5 2-2 v SouthamptonNewcastle United 2-2 Southampton | Premier League |
| 3 | Sat 20 Nov 2021 | 53-3 v BrentfordNewcastle United 3-3 Brentford | Premier League |
| 4 | Sat 27 Nov 2021 | 50-2 v ArsenalArsenal 2-0 Newcastle United | Premier League |
| 5 | Tue 30 Nov 2021 | 51-1 v Norwich CityNewcastle United 1-1 Norwich City | Premier League |
| 6 | Sat 4 Dec 2021 | 51-0 v BurnleyNewcastle United 1-0 Burnley | Premier League |
| 7 | Sun 12 Dec 2021 | 50-4 v Leicester CityLeicester City 4-0 Newcastle United | Premier League |
| 8 | Thu 16 Dec 2021 | 51-3 v LiverpoolLiverpool 3-1 Newcastle United | Premier League |
| 9 | Mon 27 Dec 2021 | 51-1 v Manchester UnitedNewcastle United 1-1 Manchester United | Premier League |
| 10 | Sat 8 Jan 2022 | 50-1 v Cambridge UnitedNewcastle United 0-1 Cambridge United | Emirates FA Cup Third Round |
| 11 | Sat 15 Jan 2022 | 51-1 v WatfordNewcastle United 1-1 Watford | Premier League |
| 12 | Sat 22 Jan 2022 | 51-0 v Leeds UnitedLeeds United 0-1 Newcastle United | Premier League |
| 13 | Tue 8 Feb 2022 | 5 3-1 v EvertonNewcastle United 3-1 Everton | Premier League |
| 14 | Sun 13 Feb 2022 | 51-0 v Aston VillaNewcastle United 1-0 Aston Villa | Premier League |
| 15 | Sat 19 Feb 2022 | 51-1 v West Ham UnitedWest Ham United 1-1 Newcastle United | Premier League |
| 16 | Sat 26 Feb 2022 | 52-0 v BrentfordBrentford 0-2 Newcastle United | Premier League |
| 17 | Sat 5 Mar 2022 | 52-1 v Brighton & Hove AlbionNewcastle United 2-1 Brighton & Hove Albion | Premier League |
| 18 | Thu 10 Mar 2022 | 52-1 v SouthamptonSouthampton 1-2 Newcastle United | Premier League |
| 19 | Sun 13 Mar 2022 | 50-1 v ChelseaChelsea 1-0 Newcastle United | Premier League |
| 20 | Thu 17 Mar 2022 | 50-1 v EvertonEverton 1-0 Newcastle United | Premier League |
| 21 | Sun 3 Apr 2022 | 51-5 v Tottenham HotspurTottenham Hotspur 5-1 Newcastle United | Premier League |
| 22 | Fri 8 Apr 2022 | 5 1-0 v Wolverhampton WanderersNewcastle United 1-0 Wolverhampton Wanderers | Premier League |
| 23 | Sun 17 Apr 2022 | 52-1 v Leicester CityNewcastle United 2-1 Leicester City | Premier League |
| 24 | Wed 20 Apr 2022 | 51-0 v Crystal PalaceNewcastle United 1-0 Crystal Palace | Premier League |
| 25 | Sat 30 Apr 2022 | 50-1 v LiverpoolNewcastle United 0-1 Liverpool | Premier League |
| 26 | Mon 16 May 2022 | 52-0 v ArsenalNewcastle United 2-0 Arsenal | Premier League |
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