| 1 | Sat 23 Aug | 82-0 v SassuoloSassuolo 0-2 Napoli | Italian Serie A |
| 2 | Sat 30 Aug | 81-0 v CagliariNapoli 1-0 Cagliari | Italian Serie A |
| 3 | Sat 13 Sep | 83-1 v FiorentinaFiorentina 1-3 Napoli | Italian Serie A |
| 4 | Thu 18 Sep | 80-2 v Manchester CityManchester City 2-0 Napoli | UEFA Champions League Matchday 1 |
| 5 | Mon 22 Sep | 83-2 v PisaNapoli 3-2 Pisa | Italian Serie A |
| 6 | Sun 28 Sep | 81-2 v AC MilanAC Milan 2-1 Napoli | Italian Serie A |
| 7 | Wed 1 Oct | 82-1 v Sporting CPNapoli 2-1 Sporting CP | UEFA Champions League Matchday 2 |
| 8 | Sun 5 Oct | 82-1 v GenoaNapoli 2-1 Genoa | Italian Serie A |
| 9 | Tue 21 Oct | 82-6 v PSV EindhovenPSV Eindhoven 6-2 Napoli | UEFA Champions League Matchday 3 |
| 10 | Sat 25 Oct | 83-1 v Inter MilanNapoli 3-1 Inter Milan | Italian Serie A |
| 11 | Tue 28 Oct | 81-0 v LecceLecce 0-1 Napoli | Italian Serie A |
| 12 | Sat 1 Nov | 80-0 v Como 1907Napoli 0-0 Como 1907 | Italian Serie A |
| 13 | Tue 4 Nov | 80-0 v Eintracht FrankfurtNapoli 0-0 Eintracht Frankfurt | UEFA Champions League Matchday 4 |
| 14 | Sun 9 Nov | 80-2 v BolognaBologna 2-0 Napoli | Italian Serie A |
| 15 | Sat 22 Nov | 83-1 v AtalantaNapoli 3-1 Atalanta | Italian Serie A |
| 16 | Tue 25 Nov | 82-0 v FK QarabağNapoli 2-0 FK Qarabağ | UEFA Champions League Matchday 5 |
| 17 | Sun 30 Nov | 81-0 v RomaRoma 0-1 Napoli | Italian Serie A |
| 18 | Sun 7 Dec | 82-1 v JuventusNapoli 2-1 Juventus | Italian Serie A |
| 19 | Wed 10 Dec | 80-2 v BenficaBenfica 2-0 Napoli | UEFA Champions League Matchday 6 |
| 20 | Sun 14 Dec | 80-1 v UdineseUdinese 1-0 Napoli | Italian Serie A |
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