| 1 | Sat 30 Aug | 41-0 v CagliariNapoli 1-0 Cagliari | Italian Serie A |
| 2 | Sat 13 Sep | 43-1 v FiorentinaFiorentina 1-3 Napoli | Italian Serie A |
| 3 | Thu 18 Sep | 40-2 v Manchester CityManchester City 2-0 Napoli | UEFA Champions League Matchday 1 |
| 4 | Mon 22 Sep | 43-2 v PisaNapoli 3-2 Pisa | Italian Serie A |
| 5 | Sat 18 Oct | 40-1 v TorinoTorino 1-0 Napoli | Italian Serie A |
| 6 | Tue 21 Oct | 42-6 v PSV EindhovenPSV Eindhoven 6-2 Napoli | UEFA Champions League Matchday 3 |
| 7 | Sat 25 Oct | 43-1 v Inter MilanNapoli 3-1 Inter Milan | Italian Serie A |
| 8 | Tue 28 Oct | 41-0 v LecceLecce 0-1 Napoli | Italian Serie A |
| 9 | Sat 1 Nov | 40-0 v Como 1907Napoli 0-0 Como 1907 | Italian Serie A |
| 10 | Tue 4 Nov | 40-0 v Eintracht FrankfurtNapoli 0-0 Eintracht Frankfurt | UEFA Champions League Matchday 4 |
| 11 | Sun 9 Nov | 40-2 v BolognaBologna 2-0 Napoli | Italian Serie A |
| 12 | Sat 22 Nov | 43-1 v AtalantaNapoli 3-1 Atalanta | Italian Serie A |
| 13 | Tue 25 Nov | 42-0 v FK QarabağNapoli 2-0 FK Qarabağ | UEFA Champions League Matchday 5 |
| 14 | Sun 30 Nov | 41-0 v RomaRoma 0-1 Napoli | Italian Serie A |
| 15 | Sun 7 Dec | 4 2-1 v JuventusNapoli 2-1 Juventus | Italian Serie A |
| 16 | Wed 10 Dec | 40-2 v BenficaBenfica 2-0 Napoli | UEFA Champions League Matchday 6 |
| 17 | Sun 14 Dec | 40-1 v UdineseUdinese 1-0 Napoli | Italian Serie A |
| 18 | Sun 28 Dec | 42-0 v CremoneseCremonese 0-2 Napoli | Italian Serie A |
| 19 | Sun 4 Jan | 42-0 v LazioLazio 0-2 Napoli | Italian Serie A |
| 20 | Wed 7 Jan | 42-2 v Hellas VeronaNapoli 2-2 Hellas Verona | Italian Serie A |
| 21 | Wed 14 Jan | 40-0 v ParmaNapoli 0-0 Parma | Italian Serie A |
| 22 | Sat 17 Jan | 41-0 v SassuoloNapoli 1-0 Sassuolo | Italian Serie A |
| 23 | Tue 20 Jan | 41-1 v FC CopenhagenFC Copenhagen 1-1 Napoli | UEFA Champions League Matchday 7 |
| 24 | Sun 25 Jan | 40-3 v JuventusJuventus 3-0 Napoli | Italian Serie A |
| 25 | Wed 28 Jan | 42-3 v ChelseaNapoli 2-3 Chelsea | UEFA Champions League Matchday 8 |
| 26 | Sat 31 Jan | 4 2-1 v FiorentinaNapoli 2-1 Fiorentina | Italian Serie A |
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