| 1 | Sun 1 Aug 2021 | 3 2-3 v HibernianMotherwell 2-3 Hibernian | Cinch Premiership |
| 2 | Sun 8 Aug 2021 | 31-1 v St JohnstoneSt Johnstone 1-1 Motherwell | Cinch Premiership |
| 3 | Sat 21 Aug 2021 | 32-1 v LivingstonLivingston 1-2 Motherwell | Cinch Premiership |
| 4 | Sat 28 Aug 2021 | 3 1-0 v DundeeMotherwell 1-0 Dundee | Cinch Premiership |
| 5 | Sat 25 Sep 2021 | 32-1 v Ross CountyMotherwell 2-1 Ross County | Cinch Premiership |
| 6 | Wed 27 Oct 2021 | 32-2 v St MirrenMotherwell 2-2 St Mirren | Cinch Premiership |
| 7 | Sat 6 Nov 2021 | 32-0 v AberdeenAberdeen 0-2 Motherwell | Cinch Premiership |
| 8 | Tue 30 Nov 2021 | 31-0 v Dundee UnitedMotherwell 1-0 Dundee United | Cinch Premiership |
| 9 | Sat 4 Dec 2021 | 31-1 v HibernianHibernian 1-1 Motherwell | Cinch Premiership |
| 10 | Sun 12 Dec 2021 | 30-1 v CelticCeltic 1-0 Motherwell | Cinch Premiership |
| 11 | Sat 18 Dec 2021 | 32-0 v St JohnstoneMotherwell 2-0 St Johnstone | Cinch Premiership |
| 12 | Wed 26 Jan 2022 | 30-0 v HibernianMotherwell 0-0 Hibernian | Cinch Premiership |
| 13 | Sat 29 Jan 2022 | 30-2 v Heart of MidlothianHeart of Midlothian 2-0 Motherwell | Cinch Premiership |
| 14 | Tue 1 Feb 2022 | 31-1 v St MirrenSt Mirren 1-1 Motherwell | Cinch Premiership |
| 15 | Sun 6 Feb 2022 | 30-4 v CelticMotherwell 0-4 Celtic | Cinch Premiership |
| 16 | Sat 12 Feb 2022 | 3 2-1 v AberdeenMotherwell 2-1 Aberdeen | William Hill Scottish Cup Fifth Round |
| 17 | Sat 19 Feb 2022 | 31-1 v AberdeenMotherwell 1-1 Aberdeen | Cinch Premiership |
| 18 | Sun 27 Feb 2022 | 32-2 v RangersRangers 2-2 Motherwell | Cinch Premiership |
| 19 | Wed 2 Mar 2022 | 30-1 v Ross CountyMotherwell 0-1 Ross County | Cinch Premiership |
| 20 | Sat 19 Mar 2022 | 31-2 v St JohnstoneSt Johnstone 2-1 Motherwell | Cinch Premiership |
| 21 | Sat 9 Apr 2022 | 32-2 v LivingstonLivingston 2-2 Motherwell | Cinch Premiership |
| 22 | Sat 23 Apr 2022 | 31-3 v RangersMotherwell 1-3 Rangers | Cinch Premiership |
| 23 | Sat 30 Apr 2022 | 30-1 v Dundee UnitedDundee United 1-0 Motherwell | Cinch Premiership |
| 24 | Sat 7 May 2022 | 31-0 v Ross CountyRoss County 0-1 Motherwell | Cinch Premiership |
| 25 | Wed 11 May 2022 | 32-1 v Heart of MidlothianMotherwell 2-1 Heart of Midlothian | Cinch Premiership |
| 26 | Sat 14 May 2022 | 30-6 v CelticCeltic 6-0 Motherwell | Cinch Premiership |
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