| 1 | Sun 15 Aug 2021 | 33-3 v ReimsReims 3-3 Montpellier | French Ligue 1 |
| 2 | Sun 22 Aug 2021 | 33-1 v LorientMontpellier 3-1 Lorient | French Ligue 1 |
| 3 | Sun 29 Aug 2021 | 31-2 v LilleLille 2-1 Montpellier | French Ligue 1 |
| 4 | Sun 12 Sep 2021 | 32-0 v Saint ÉtienneMontpellier 2-0 Saint Étienne | French Ligue 1 |
| 5 | Sat 2 Oct 2021 | 3 1-1 v StrasbourgMontpellier 1-1 Strasbourg | French Ligue 1 |
| 6 | Sun 17 Oct 2021 | 31-0 v LensMontpellier 1-0 Lens | French Ligue 1 |
| 7 | Sun 24 Oct 2021 | 31-3 v MonacoMonaco 3-1 Montpellier | French Ligue 1 |
| 8 | Sun 31 Oct 2021 | 3 2-0 v NantesMontpellier 2-0 Nantes | French Ligue 1 |
| 9 | Sun 7 Nov 2021 | 31-0 v NiceNice 0-1 Montpellier | French Ligue 1 |
| 10 | Sat 20 Nov 2021 | 30-2 v RennesRennes 2-0 Montpellier | French Ligue 1 |
| 11 | Sun 28 Nov 2021 | 30-1 v LyonMontpellier 0-1 Lyon | French Ligue 1 |
| 12 | Wed 1 Dec 2021 | 33-1 v MetzMetz 1-3 Montpellier | French Ligue 1 |
| 13 | Sat 11 Dec 2021 | 34-0 v BrestBrest 0-4 Montpellier | French Ligue 1 |
| 14 | Wed 22 Dec 2021 | 34-1 v AngersMontpellier 4-1 Angers | French Ligue 1 |
| 15 | Sun 16 Jan 2022 | 31-3 v StrasbourgStrasbourg 3-1 Montpellier | French Ligue 1 |
| 16 | Sun 23 Jan 2022 | 33-2 v MonacoMontpellier 3-2 Monaco | French Ligue 1 |
| 17 | Sat 5 Feb 2022 | 31-3 v Saint ÉtienneSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 18 | Sat 12 Feb 2022 | 30-1 v LilleMontpellier 0-1 Lille | French Ligue 1 |
| 19 | Sun 20 Feb 2022 | 31-0 v LorientLorient 0-1 Montpellier | French Ligue 1 |
| 20 | Sun 3 Apr 2022 | 3 1-2 v BrestMontpellier 1-2 Brest | French Ligue 1 |
| 21 | Sun 10 Apr 2022 | 30-2 v MarseilleMarseille 2-0 Montpellier | French Ligue 1 |
| 22 | Sun 17 Apr 2022 | 30-0 v ReimsMontpellier 0-0 Reims | French Ligue 1 |
| 23 | Wed 20 Apr 2022 | 30-2 v LensLens 2-0 Montpellier | French Ligue 1 |
| 24 | Sat 23 Apr 2022 | 32-5 v LyonLyon 5-2 Montpellier | French Ligue 1 |
| 25 | Sun 1 May 2022 | 32-2 v MetzMontpellier 2-2 Metz | French Ligue 1 |
| 26 | Sun 8 May 2022 | 31-2 v ClermontClermont 2-1 Montpellier | French Ligue 1 |
| 27 | Sat 21 May 2022 | 30-2 v AngersAngers 2-0 Montpellier | French Ligue 1 |
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