| 1 | Sat 15 Jan 2022 | 12-1 v PortsmouthPortsmouth 1-2 Milton Keynes Dons | Sky Bet League One |
| 2 | Sat 22 Jan 2022 | 10-1 v Doncaster RoversMilton Keynes Dons 0-1 Doncaster Rovers | Sky Bet League One |
| 3 | Tue 25 Jan 2022 | 11-0 v Burton AlbionBurton Albion 0-1 Milton Keynes Dons | Sky Bet League One |
| 4 | Sat 29 Jan 2022 | 11-0 v Wycombe WanderersWycombe Wanderers 0-1 Milton Keynes Dons | Sky Bet League One |
| 5 | Sat 5 Feb 2022 | 12-1 v Lincoln CityMilton Keynes Dons 2-1 Lincoln City | Sky Bet League One |
| 6 | Tue 8 Feb 2022 | 11-1 v Fleetwood TownFleetwood Town 1-1 Milton Keynes Dons | Sky Bet League One |
| 7 | Sat 12 Feb 2022 | 10-0 v Ipswich TownMilton Keynes Dons 0-0 Ipswich Town | Sky Bet League One |
| 8 | Sat 19 Feb 2022 | 12-1 v SunderlandSunderland 1-2 Milton Keynes Dons | Sky Bet League One |
| 9 | Tue 22 Feb 2022 | 12-0 v Charlton AthleticCharlton Athletic 0-2 Milton Keynes Dons | Sky Bet League One |
| 10 | Sat 26 Feb 2022 | 12-0 v Bolton WanderersMilton Keynes Dons 2-0 Bolton Wanderers | Sky Bet League One |
| 11 | Sat 5 Mar 2022 | 12-1 v Rotherham UnitedRotherham United 1-2 Milton Keynes Dons | Sky Bet League One |
| 12 | Tue 8 Mar 2022 | 13-1 v Cheltenham TownMilton Keynes Dons 3-1 Cheltenham Town | Sky Bet League One |
| 13 | Sat 12 Mar 2022 | 11-1 v Wigan AthleticMilton Keynes Dons 1-1 Wigan Athletic | Sky Bet League One |
| 14 | Sat 19 Mar 2022 | 11-0 v Cambridge UnitedCambridge United 0-1 Milton Keynes Dons | Sky Bet League One |
| 15 | Sat 2 Apr 2022 | 12-0 v Shrewsbury TownMilton Keynes Dons 2-0 Shrewsbury Town | Sky Bet League One |
| 16 | Tue 5 Apr 2022 | 12-1 v Crewe AlexandraMilton Keynes Dons 2-1 Crewe Alexandra | Sky Bet League One |
| 17 | Sat 9 Apr 2022 | 11-1 v AFC WimbledonAFC Wimbledon 1-1 Milton Keynes Dons | Sky Bet League One |
| 18 | Sat 16 Apr 2022 | 12-3 v Sheffield WednesdayMilton Keynes Dons 2-3 Sheffield Wednesday | Sky Bet League One |
| 19 | Tue 19 Apr 2022 | 10-1 v Oxford UnitedOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 20 | Sat 23 Apr 2022 | 12-0 v MorecambeMilton Keynes Dons 2-0 Morecambe | Sky Bet League One |
| 21 | Sat 30 Apr 2022 | 15-0 v Plymouth ArgylePlymouth Argyle 0-5 Milton Keynes Dons | Sky Bet League One |
| 22 | Thu 5 May 2022 | 10-2 v Wycombe WanderersWycombe Wanderers 2-0 Milton Keynes Dons | Sky Bet League One Play-off Semi Final |
| 23 | Sun 8 May 2022 | 11-0 v Wycombe WanderersMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One Play-off Semi Final |
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