| 1 | Sat 14 Aug 2021 | 11-2 v SunderlandMilton Keynes Dons 1-2 Sunderland | Sky Bet League One |
| 2 | Tue 17 Aug 2021 | 12-1 v Charlton AthleticMilton Keynes Dons 2-1 Charlton Athletic | Sky Bet League One |
| 3 | Sat 21 Aug 2021 | 12-2 v Ipswich TownIpswich Town 2-2 Milton Keynes Dons | Sky Bet League One |
| 4 | Sat 28 Aug 2021 | 12-0 v Accrington StanleyMilton Keynes Dons 2-0 Accrington Stanley | Sky Bet League One |
| 5 | Sat 4 Sep 2021 | 11-1 v Cheltenham TownCheltenham Town 1-1 Milton Keynes Dons | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 1 1-0 v PortsmouthMilton Keynes Dons 1-0 Portsmouth | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 14-1 v GillinghamGillingham 1-4 Milton Keynes Dons | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 11-0 v Wycombe WanderersMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 13-3 v Fleetwood TownMilton Keynes Dons 3-3 Fleetwood Town | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 11-2 v Doncaster RoversDoncaster Rovers 2-1 Milton Keynes Dons | Sky Bet League One |
| 11 | Sat 16 Oct 2021 | 10-1 v Shrewsbury TownShrewsbury Town 1-0 Milton Keynes Dons | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 12-1 v Wigan AthleticWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 10-3 v Rotherham UnitedMilton Keynes Dons 0-3 Rotherham United | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 14-1 v Crewe AlexandraCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 15 | Sat 6 Nov 2021 | 12-2 v StevenageMilton Keynes Dons 2-2 Stevenage | Emirates FA Cup First Round |
| 16 | Sat 13 Nov 2021 | 14-1 v Cambridge UnitedMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 17 | Tue 16 Nov 2021 | 11-2 v StevenageStevenage 2-1 Milton Keynes Dons | Emirates FA Cup First Round Replay |
| 18 | Sat 20 Nov 2021 | 11-0 v Burton AlbionMilton Keynes Dons 1-0 Burton Albion | Sky Bet League One |
| 19 | Tue 23 Nov 2021 | 11-2 v Sheffield WednesdaySheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 20 | Sat 27 Nov 2021 | 14-0 v MorecambeMorecambe 0-4 Milton Keynes Dons | Sky Bet League One |
| 21 | Wed 8 Dec 2021 | 11-1 v Plymouth ArgyleMilton Keynes Dons 1-1 Plymouth Argyle | Sky Bet League One |
| 22 | Sat 11 Dec 2021 | 11-2 v Oxford UnitedMilton Keynes Dons 1-2 Oxford United | Sky Bet League One |
| 23 | Sun 26 Dec 2021 | 13-2 v Lincoln CityLincoln City 2-3 Milton Keynes Dons | Sky Bet League One |
| 24 | Sat 1 Jan 2022 | 10-0 v GillinghamMilton Keynes Dons 0-0 Gillingham | Sky Bet League One |
| 25 | Sat 8 Jan 2022 | 11-1 v Accrington StanleyAccrington Stanley 1-1 Milton Keynes Dons | Sky Bet League One |
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