| 1 | Sun 9 Aug 2020 | 32-2 v RSC AnderlechtMechelen 2-2 RSC Anderlecht | Belgian First Division A |
| 2 | Fri 14 Aug 2020 | 31-0 v Royal Excel MouscronRoyal Excel Mouscron 0-1 Mechelen | Belgian First Division A |
| 3 | Sat 22 Aug 2020 | 3 2-3 v Cercle BruggeMechelen 2-3 Cercle Brugge | Belgian First Division A |
| 4 | Sun 30 Aug 2020 | 30-1 v KAA GentKAA Gent 1-0 Mechelen | Belgian First Division A |
| 5 | Sat 12 Sep 2020 | 3 0-1 v KV OostendeMechelen 0-1 KV Oostende | Belgian First Division A |
| 6 | Sun 20 Sep 2020 | 31-3 v KRC GenkKRC Genk 3-1 Mechelen | Belgian First Division A |
| 7 | Sat 26 Sep 2020 | 32-0 v Sint-Truidense VVMechelen 2-0 Sint-Truidense VV | Belgian First Division A |
| 8 | Fri 2 Oct 2020 | 3 1-4 v Royal AntwerpRoyal Antwerp 4-1 Mechelen | Belgian First Division A |
| 9 | Sat 17 Oct 2020 | 31-2 v KV KortrijkMechelen 1-2 KV Kortrijk | Belgian First Division A |
| 10 | Sat 31 Oct 2020 | 32-2 v Club BruggeClub Brugge 2-2 Mechelen | Belgian First Division A |
| 11 | Sun 20 Dec 2020 | 32-1 v Oud-Heverlee LeuvenOud-Heverlee Leuven 1-2 Mechelen | Belgian First Division A |
| 12 | Sun 27 Dec 2020 | 32-1 v Royal Excel MouscronMechelen 2-1 Royal Excel Mouscron | Belgian First Division A |
| 13 | Sun 10 Jan 2021 | 33-0 v Royal AntwerpMechelen 3-0 Royal Antwerp | Belgian First Division A |
| 14 | Sat 16 Jan 2021 | 31-0 v Sporting de CharleroiSporting de Charleroi 0-1 Mechelen | Belgian First Division A |
| 15 | Wed 20 Jan 2021 | 30-4 v Standard LiègeMechelen 0-4 Standard Liège | Belgian First Division A |
| 16 | Sat 23 Jan 2021 | 33-0 v KAS EupenMechelen 3-0 KAS Eupen | Belgian First Division A |
| 17 | Tue 26 Jan 2021 | 33-2 v Waasland-BeverenWaasland-Beveren 2-3 Mechelen | Belgian First Division A |
| 18 | Sat 30 Jan 2021 | 3 0-0 v KRC GenkMechelen 0-0 KRC Genk | Belgian First Division A |
| 19 | Sat 6 Feb 2021 | 31-0 v Cercle BruggeCercle Brugge 0-1 Mechelen | Belgian First Division A |
| 20 | Sun 14 Feb 2021 | 32-1 v Germinal BeerschotGerminal Beerschot 1-2 Mechelen | Belgian First Division A |
| 21 | Fri 19 Feb 2021 | 31-1 v KAA GentMechelen 1-1 KAA Gent | Belgian First Division A |
| 22 | Sat 27 Feb 2021 | 30-2 v KV OostendeKV Oostende 2-0 Mechelen | Belgian First Division A |
| 23 | Sun 7 Mar 2021 | 31-1 v RSC AnderlechtRSC Anderlecht 1-1 Mechelen | Belgian First Division A |
| 24 | Sun 21 Mar 2021 | 3 2-2 v Oud-Heverlee LeuvenMechelen 2-2 Oud-Heverlee Leuven | Belgian First Division A |
| 25 | Sat 10 Apr 2021 | 3 4-2 v SV Zulte WaregemMechelen 4-2 SV Zulte Waregem | Belgian First Division A |
| 26 | Sun 18 Apr 2021 | 34-1 v KV KortrijkKV Kortrijk 1-4 Mechelen | Belgian First Division A |
| 27 | Sun 2 May 2021 | 32-2 v KAA GentKAA Gent 2-2 Mechelen | Belgian First Division A Play-off |
| 28 | Sun 9 May 2021 | 35-3 v KV OostendeMechelen 5-3 KV Oostende | Belgian First Division A Play-off |
| 29 | Thu 13 May 2021 | 3 2-1 v Standard LiègeStandard Liège 1-2 Mechelen | Belgian First Division A Play-off |
| 30 | Sun 16 May 2021 | 33-1 v Standard LiègeMechelen 3-1 Standard Liège | Belgian First Division A Play-off |
| 31 | Wed 19 May 2021 | 32-2 v KV OostendeKV Oostende 2-2 Mechelen | Belgian First Division A Play-off |
| 32 | Sat 22 May 2021 | 31-2 v KAA GentMechelen 1-2 KAA Gent | Belgian First Division A Play-off |
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