| 1 | Sat 22 Jan 2022 | 343-1 v BarrowBarrow 1-3 Mansfield Town | Sky Bet League Two |
| 2 | Sat 29 Jan 2022 | 342-0 v Leyton OrientMansfield Town 2-0 Leyton Orient | Sky Bet League Two |
| 3 | Tue 1 Feb 2022 | 340-0 v Harrogate TownHarrogate Town 0-0 Mansfield Town | Sky Bet League Two |
| 4 | Tue 8 Feb 2022 | 34 2-1 v Colchester UnitedMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 5 | Sat 12 Feb 2022 | 340-0 v Bristol RoversBristol Rovers 0-0 Mansfield Town | Sky Bet League Two |
| 6 | Sat 19 Feb 2022 | 341-1 v Newport CountyNewport County 1-1 Mansfield Town | Sky Bet League Two |
| 7 | Sat 26 Feb 2022 | 342-0 v Bradford CityBradford City 0-2 Mansfield Town | Sky Bet League Two |
| 8 | Fri 4 Mar 2022 | 342-1 v Exeter CityMansfield Town 2-1 Exeter City | Sky Bet League Two |
| 9 | Fri 11 Mar 2022 | 342-3 v Tranmere RoversTranmere Rovers 3-2 Mansfield Town | Sky Bet League Two |
| 10 | Tue 29 Mar 2022 | 342-2 v Hartlepool UnitedHartlepool United 2-2 Mansfield Town | Sky Bet League Two |
| 11 | Sat 2 Apr 2022 | 341-0 v Northampton TownMansfield Town 1-0 Northampton Town | Sky Bet League Two |
| 12 | Tue 5 Apr 2022 | 340-1 v Forest Green RoversForest Green Rovers 1-0 Mansfield Town | Sky Bet League Two |
| 13 | Sat 9 Apr 2022 | 34 4-0 v Scunthorpe UnitedScunthorpe United 0-4 Mansfield Town | Sky Bet League Two |
| 14 | Fri 15 Apr 2022 | 342-3 v Sutton UnitedMansfield Town 2-3 Sutton United | Sky Bet League Two |
| 15 | Mon 18 Apr 2022 | 340-1 v Carlisle UnitedCarlisle United 1-0 Mansfield Town | Sky Bet League Two |
| 16 | Sat 23 Apr 2022 | 342-0 v Crawley TownMansfield Town 2-0 Crawley Town | Sky Bet League Two |
| 17 | Tue 26 Apr 2022 | 342-0 v StevenageMansfield Town 2-0 Stevenage | Sky Bet League Two |
| 18 | Mon 2 May 2022 | 342-2 v Salford CitySalford City 2-2 Mansfield Town | Sky Bet League Two |
| 19 | Sat 7 May 2022 | 342-2 v Forest Green RoversMansfield Town 2-2 Forest Green Rovers | Sky Bet League Two |
| 20 | Sat 14 May 2022 | 342-1 v Northampton TownMansfield Town 2-1 Northampton Town | Sky Bet League Two Play-off Semi Final |
| 21 | Wed 18 May 2022 | 341-0 v Northampton TownNorthampton Town 0-1 Mansfield Town | Sky Bet League Two Play-off Semi Final |
| 22 | Sat 28 May 2022 | 340-3 v Port ValeMansfield Town 0-3 Port Vale | Sky Bet League Two Play-off Final |
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