| 1 | Wed 22 Sep 2021 | 270-1 v West Ham UnitedManchester United 0-1 West Ham United | Carabao Cup Third Round |
| 2 | Wed 29 Sep 2021 | 27 2-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 3 | Sat 6 Nov 2021 | 270-2 v Manchester CityManchester United 0-2 Manchester City | Premier League |
| 4 | Tue 23 Nov 2021 | 272-0 v VillarrealVillarreal 0-2 Manchester United | UEFA Champions League Group F |
| 5 | Sun 28 Nov 2021 | 271-1 v ChelseaChelsea 1-1 Manchester United | Premier League |
| 6 | Thu 2 Dec 2021 | 273-2 v ArsenalManchester United 3-2 Arsenal | Premier League |
| 7 | Sun 5 Dec 2021 | 271-0 v Crystal PalaceManchester United 1-0 Crystal Palace | Premier League |
| 8 | Sat 11 Dec 2021 | 271-0 v Norwich CityNorwich City 0-1 Manchester United | Premier League |
| 9 | Mon 27 Dec 2021 | 271-1 v Newcastle UnitedNewcastle United 1-1 Manchester United | Premier League |
| 10 | Sat 15 Jan 2022 | 272-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 11 | Wed 19 Jan 2022 | 273-1 v BrentfordBrentford 1-3 Manchester United | Premier League |
| 12 | Sat 22 Jan 2022 | 271-0 v West Ham UnitedManchester United 1-0 West Ham United | Premier League |
| 13 | Tue 15 Feb 2022 | 272-0 v Brighton & Hove AlbionManchester United 2-0 Brighton & Hove Albion | Premier League |
| 14 | Wed 23 Feb 2022 | 27 1-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 15 | Sat 26 Feb 2022 | 270-0 v WatfordManchester United 0-0 Watford | Premier League |
| 16 | Sun 6 Mar 2022 | 271-4 v Manchester CityManchester City 4-1 Manchester United | Premier League |
| 17 | Sat 12 Mar 2022 | 273-2 v Tottenham HotspurManchester United 3-2 Tottenham Hotspur | Premier League |
| 18 | Tue 15 Mar 2022 | 270-1 v Atlético MadridManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 19 | Sat 2 Apr 2022 | 271-1 v Leicester CityManchester United 1-1 Leicester City | Premier League |
| 20 | Sat 9 Apr 2022 | 270-1 v EvertonEverton 1-0 Manchester United | Premier League |
| 21 | Sat 16 Apr 2022 | 273-2 v Norwich CityManchester United 3-2 Norwich City | Premier League |
| 22 | Sat 23 Apr 2022 | 27 1-3 v ArsenalArsenal 3-1 Manchester United | Premier League |
| 23 | Thu 28 Apr 2022 | 271-1 v ChelseaManchester United 1-1 Chelsea | Premier League |
| 24 | Mon 2 May 2022 | 273-0 v BrentfordManchester United 3-0 Brentford | Premier League |
| 25 | Sat 7 May 2022 | 270-4 v Brighton & Hove AlbionBrighton & Hove Albion 4-0 Manchester United | Premier League |
| 26 | Sun 22 May 2022 | 270-1 v Crystal PalaceCrystal Palace 1-0 Manchester United | Premier League |
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