| 1 | Sat 14 Aug 2021 | 295-1 v Leeds UnitedManchester United 5-1 Leeds United | Premier League |
| 2 | Sun 22 Aug 2021 | 291-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 3 | Sun 29 Aug 2021 | 291-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 4 | Sat 11 Sep 2021 | 294-1 v Newcastle UnitedManchester United 4-1 Newcastle United | Premier League |
| 5 | Tue 14 Sep 2021 | 29 1-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 6 | Sun 19 Sep 2021 | 292-1 v West Ham UnitedWest Ham United 1-2 Manchester United | Premier League |
| 7 | Sat 25 Sep 2021 | 290-1 v Aston VillaManchester United 0-1 Aston Villa | Premier League |
| 8 | Sat 2 Oct 2021 | 291-1 v EvertonManchester United 1-1 Everton | Premier League |
| 9 | Sat 16 Oct 2021 | 29 2-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 10 | Wed 20 Oct 2021 | 293-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 11 | Sun 24 Oct 2021 | 29 0-5 v LiverpoolManchester United 0-5 Liverpool | Premier League |
| 12 | Sat 30 Oct 2021 | 293-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 13 | Tue 2 Nov 2021 | 292-2 v AtalantaAtalanta 2-2 Manchester United | UEFA Champions League Group F |
| 14 | Sat 6 Nov 2021 | 290-2 v Manchester CityManchester United 0-2 Manchester City | Premier League |
| 15 | Sat 20 Nov 2021 | 291-4 v WatfordWatford 4-1 Manchester United | Premier League |
| 16 | Tue 23 Nov 2021 | 292-0 v VillarrealVillarreal 0-2 Manchester United | UEFA Champions League Group F |
| 17 | Sun 28 Nov 2021 | 291-1 v ChelseaChelsea 1-1 Manchester United | Premier League |
| 18 | Wed 8 Dec 2021 | 291-1 v Young BoysManchester United 1-1 Young Boys | UEFA Champions League Group F |
| 19 | Thu 30 Dec 2021 | 293-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 20 | Mon 3 Jan 2022 | 290-1 v Wolverhampton WanderersManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 21 | Sun 20 Feb 2022 | 294-2 v Leeds UnitedLeeds United 2-4 Manchester United | Premier League |
| 22 | Wed 23 Feb 2022 | 291-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 23 | Sat 26 Feb 2022 | 290-0 v WatfordManchester United 0-0 Watford | Premier League |
| 24 | Sun 6 Mar 2022 | 291-4 v Manchester CityManchester City 4-1 Manchester United | Premier League |
| 25 | Sat 9 Apr 2022 | 290-1 v EvertonEverton 1-0 Manchester United | Premier League |
| 26 | Tue 19 Apr 2022 | 290-4 v LiverpoolLiverpool 4-0 Manchester United | Premier League |
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