| 1 | Sat 19 Sep 2020 | 391-3 v Crystal PalaceManchester United 1-3 Crystal Palace | Premier League |
| 2 | Wed 30 Sep 2020 | 393-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-3 Manchester United | Carabao Cup Fourth Round |
| 3 | Sun 4 Oct 2020 | 391-6 v Tottenham HotspurManchester United 1-6 Tottenham Hotspur | Premier League |
| 4 | Sat 17 Oct 2020 | 394-1 v Newcastle UnitedNewcastle United 1-4 Manchester United | Premier League |
| 5 | Tue 20 Oct 2020 | 39 2-1 v Paris St GermainParis St Germain 1-2 Manchester United | UEFA Champions League Group H |
| 6 | Sat 24 Oct 2020 | 390-0 v ChelseaManchester United 0-0 Chelsea | Premier League |
| 7 | Wed 28 Oct 2020 | 395-0 v RB LeipzigManchester United 5-0 RB Leipzig | UEFA Champions League Group H |
| 8 | Sun 1 Nov 2020 | 390-1 v ArsenalManchester United 0-1 Arsenal | Premier League |
| 9 | Wed 4 Nov 2020 | 391-2 v İstanbul Başakşehirİstanbul Başakşehir 2-1 Manchester United | UEFA Champions League Group H |
| 10 | Sat 7 Nov 2020 | 393-1 v EvertonEverton 1-3 Manchester United | Premier League |
| 11 | Sat 21 Nov 2020 | 391-0 v West Bromwich AlbionManchester United 1-0 West Bromwich Albion | Premier League |
| 12 | Wed 2 Dec 2020 | 391-3 v Paris St GermainManchester United 1-3 Paris St Germain | UEFA Champions League Group H |
| 13 | Sat 5 Dec 2020 | 393-1 v West Ham UnitedWest Ham United 1-3 Manchester United | Premier League |
| 14 | Tue 8 Dec 2020 | 392-3 v RB LeipzigRB Leipzig 3-2 Manchester United | UEFA Champions League Group H |
| 15 | Sat 12 Dec 2020 | 390-0 v Manchester CityManchester United 0-0 Manchester City | Premier League |
| 16 | Thu 17 Dec 2020 | 393-2 v Sheffield UnitedSheffield United 2-3 Manchester United | Premier League |
| 17 | Sun 20 Dec 2020 | 396-2 v Leeds UnitedManchester United 6-2 Leeds United | Premier League |
| 18 | Sat 26 Dec 2020 | 392-2 v Leicester CityLeicester City 2-2 Manchester United | Premier League |
| 19 | Tue 29 Dec 2020 | 391-0 v Wolverhampton WanderersManchester United 1-0 Wolverhampton Wanderers | Premier League |
| 20 | Fri 1 Jan 2021 | 392-1 v Aston VillaManchester United 2-1 Aston Villa | Premier League |
| 21 | Wed 6 Jan 2021 | 390-2 v Manchester CityManchester United 0-2 Manchester City | Carabao Cup Semi Final |
| 22 | Sat 9 Jan 2021 | 391-0 v WatfordManchester United 1-0 Watford | Emirates FA Cup Third Round |
| 23 | Tue 12 Jan 2021 | 391-0 v BurnleyBurnley 0-1 Manchester United | Premier League |
| 24 | Sun 17 Jan 2021 | 390-0 v LiverpoolLiverpool 0-0 Manchester United | Premier League |
| 25 | Wed 20 Jan 2021 | 392-1 v FulhamFulham 1-2 Manchester United | Premier League |
| 26 | Sun 24 Jan 2021 | 393-2 v LiverpoolManchester United 3-2 Liverpool | Emirates FA Cup Fourth Round |
| 27 | Sat 30 Jan 2021 | 390-0 v ArsenalArsenal 0-0 Manchester United | Premier League |
| 28 | Tue 2 Feb 2021 | 399-0 v SouthamptonManchester United 9-0 Southampton | Premier League |
| 29 | Sat 6 Feb 2021 | 393-3 v EvertonManchester United 3-3 Everton | Premier League |
| 30 | Tue 9 Feb 2021 | 391-0 v West Ham UnitedManchester United 1-0 West Ham United | Emirates FA Cup Fifth Round |
| 31 | Sun 14 Feb 2021 | 391-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Manchester United | Premier League |
| 32 | Thu 18 Feb 2021 | 394-0 v Real SociedadReal Sociedad 0-4 Manchester United | Europa League Round of 32 |
| 33 | Sun 28 Feb 2021 | 390-0 v ChelseaChelsea 0-0 Manchester United | Premier League |
| 34 | Wed 3 Mar 2021 | 390-0 v Crystal PalaceCrystal Palace 0-0 Manchester United | Premier League |
| 35 | Sun 7 Mar 2021 | 392-0 v Manchester CityManchester City 0-2 Manchester United | Premier League |
| 36 | Thu 11 Mar 2021 | 39 1-1 v AC MilanManchester United 1-1 AC Milan | Europa League Round of 16 |
| 37 | Sun 14 Mar 2021 | 39 1-0 v West Ham UnitedManchester United 1-0 West Ham United | Premier League |
| 38 | Thu 18 Mar 2021 | 391-0 v AC MilanAC Milan 0-1 Manchester United | Europa League Round of 16 |
| 39 | Sun 21 Mar 2021 | 39 1-3 v Leicester CityLeicester City 3-1 Manchester United | Emirates FA Cup Sixth Round |
| 40 | Sun 4 Apr 2021 | 392-1 v Brighton & Hove AlbionManchester United 2-1 Brighton & Hove Albion | Premier League |
| 41 | Thu 8 Apr 2021 | 39 2-0 v GranadaGranada 0-2 Manchester United | Europa League Quarter Final |
| 42 | Sun 11 Apr 2021 | 39 3-1 v Tottenham HotspurTottenham Hotspur 1-3 Manchester United | Premier League |
| 43 | Sun 18 Apr 2021 | 393-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 44 | Sun 25 Apr 2021 | 390-0 v Leeds UnitedLeeds United 0-0 Manchester United | Premier League |
| 45 | Thu 29 Apr 2021 | 396-2 v RomaManchester United 6-2 Roma | Europa League Semi Final |
| 46 | Sun 9 May 2021 | 393-1 v Aston VillaAston Villa 1-3 Manchester United | Premier League |
| 47 | Thu 13 May 2021 | 39 2-4 v LiverpoolManchester United 2-4 Liverpool | Premier League |
| 48 | Tue 18 May 2021 | 391-1 v FulhamManchester United 1-1 Fulham | Premier League |
| 49 | Wed 26 May 2021 | 391-1 v VillarrealVillarreal 1-1 Manchester United | Europa League Final |