| 1 | Sat 11 Aug 2012 | 34-3 v Hannover 96Hannover 96 3-4 Manchester United | Friendly |
| 2 | Mon 20 Aug 2012 | 30-1 v EvertonEverton 1-0 Manchester United | Barclays Premier League |
| 3 | Sat 25 Aug 2012 | 33-2 v FulhamManchester United 3-2 Fulham | Barclays Premier League |
| 4 | Sun 2 Sep 2012 | 33-2 v SouthamptonSouthampton 2-3 Manchester United | Barclays Premier League |
| 5 | Wed 19 Sep 2012 | 31-0 v GalatasarayManchester United 1-0 Galatasaray | UEFA Champions League Group H |
| 6 | Sun 23 Sep 2012 | 32-1 v LiverpoolLiverpool 1-2 Manchester United | Barclays Premier League |
| 7 | Sat 29 Sep 2012 | 32-3 v Tottenham HotspurManchester United 2-3 Tottenham Hotspur | Barclays Premier League |
| 8 | Tue 2 Oct 2012 | 32-1 v CFR Cluj-NapocaCFR Cluj-Napoca 1-2 Manchester United | UEFA Champions League Group H |
| 9 | Sun 7 Oct 2012 | 33-0 v Newcastle UnitedNewcastle United 0-3 Manchester United | Barclays Premier League |
| 10 | Sat 20 Oct 2012 | 34-2 v Stoke CityManchester United 4-2 Stoke City | Barclays Premier League |
| 11 | Sun 28 Oct 2012 | 33-2 v ChelseaChelsea 2-3 Manchester United | Barclays Premier League |
| 12 | Sat 3 Nov 2012 | 32-1 v ArsenalManchester United 2-1 Arsenal | Barclays Premier League |
| 13 | Wed 7 Nov 2012 | 33-1 v BragaBraga 1-3 Manchester United | UEFA Champions League Group H |
| 14 | Sat 10 Nov 2012 | 33-2 v Aston VillaAston Villa 2-3 Manchester United | Barclays Premier League |
| 15 | Sat 17 Nov 2012 | 30-1 v Norwich CityNorwich City 1-0 Manchester United | Barclays Premier League |
| 16 | Sat 24 Nov 2012 | 33-1 v Queens Park RangersManchester United 3-1 Queens Park Rangers | Barclays Premier League |
| 17 | Wed 28 Nov 2012 | 31-0 v West Ham UnitedManchester United 1-0 West Ham United | Barclays Premier League |
| 18 | Sat 1 Dec 2012 | 34-3 v ReadingReading 3-4 Manchester United | Barclays Premier League |
| 19 | Sun 9 Dec 2012 | 33-2 v Manchester CityManchester City 2-3 Manchester United | Barclays Premier League |
| 20 | Sat 15 Dec 2012 | 33-1 v SunderlandManchester United 3-1 Sunderland | Barclays Premier League |
| 21 | Sun 23 Dec 2012 | 31-1 v Swansea CitySwansea City 1-1 Manchester United | Barclays Premier League |
| 22 | Wed 26 Dec 2012 | 34-3 v Newcastle UnitedManchester United 4-3 Newcastle United | Barclays Premier League |
| 23 | Sat 29 Dec 2012 | 32-0 v West Bromwich AlbionManchester United 2-0 West Bromwich Albion | Barclays Premier League |
| 24 | Tue 1 Jan 2013 | 34-0 v Wigan AthleticWigan Athletic 0-4 Manchester United | Barclays Premier League |
| 25 | Sun 13 Jan 2013 | 32-1 v LiverpoolManchester United 2-1 Liverpool | Barclays Premier League |
| 26 | Sun 20 Jan 2013 | 31-1 v Tottenham HotspurTottenham Hotspur 1-1 Manchester United | Barclays Premier League |
| 27 | Sat 26 Jan 2013 | 34-1 v FulhamManchester United 4-1 Fulham | FA Cup with Budweiser Fourth Round |
| 28 | Wed 30 Jan 2013 | 32-1 v SouthamptonManchester United 2-1 Southampton | Barclays Premier League |
| 29 | Sat 2 Feb 2013 | 31-0 v FulhamFulham 0-1 Manchester United | Barclays Premier League |
| 30 | Sun 10 Feb 2013 | 32-0 v EvertonManchester United 2-0 Everton | Barclays Premier League |
| 31 | Wed 13 Feb 2013 | 31-1 v Real MadridReal Madrid 1-1 Manchester United | UEFA Champions League First Knockout Round |
| 32 | Sat 23 Feb 2013 | 32-0 v Queens Park RangersQueens Park Rangers 0-2 Manchester United | Barclays Premier League |
| 33 | Sat 2 Mar 2013 | 34-0 v Norwich CityManchester United 4-0 Norwich City | Barclays Premier League |
| 34 | Tue 5 Mar 2013 | 31-2 v Real MadridManchester United 1-2 Real Madrid | UEFA Champions League First Knockout Round |
| 35 | Sun 10 Mar 2013 | 32-2 v ChelseaManchester United 2-2 Chelsea | FA Cup with Budweiser Quarter Final |
| 36 | Mon 1 Apr 2013 | 30-1 v ChelseaChelsea 1-0 Manchester United | FA Cup with Budweiser Quarter Final |
| 37 | Mon 8 Apr 2013 | 31-2 v Manchester CityManchester United 1-2 Manchester City | Barclays Premier League |
| 38 | Sun 14 Apr 2013 | 32-0 v Stoke CityStoke City 0-2 Manchester United | Barclays Premier League |
| 39 | Wed 17 Apr 2013 | 32-2 v West Ham UnitedWest Ham United 2-2 Manchester United | Barclays Premier League |
| 40 | Mon 22 Apr 2013 | 33-0 v Aston VillaManchester United 3-0 Aston Villa | Barclays Premier League |
| 41 | Sun 28 Apr 2013 | 31-1 v ArsenalArsenal 1-1 Manchester United | Barclays Premier League |
| 42 | Sun 5 May 2013 | 30-1 v ChelseaManchester United 0-1 Chelsea | Barclays Premier League |
| 43 | Sun 12 May 2013 | 32-1 v Swansea CityManchester United 2-1 Swansea City | Barclays Premier League |
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